Breed differences in the plasma renin activity and plasma aldosterone concentration of dogs

Zentralblatt für Veterinärmedizin. Reihe A
H D PedersenH Arnorsdottir

Abstract

Plasma renin activity (PRA) and plasma aldosterone concentration (PAC) were studied in 90 clinically healthy dogs: 15 Beagles, 15 Cavalier King Charles spaniels (CKCS), 15 Medium Sized Poodles, 15 Labrador retrievers, 15 Irish wolfhounds and 15 Newfoundlands. All dogs were fed a low sodium diet for at least 3 days before blood sampling in a home setting. There was a significant difference between breeds with respect to both PRA (P = 0.0002), PAC (P = 0.002) and PRA/PAC ratio (P < 0.0001). The highest PRA values were found in CKCS and Poodles, two breeds known to be predisposed to chronic valvular disease. Five CKCS had PRA values exceeding 3.0 ng/ml/h while this was the case in only one of the remaining 75 dogs. In contrast to the high PRA values, CKCS had low PAC values, and therefore much higher PRA/PAC ratios than the other breeds. In Irish wolfhounds, both the PRA and PAC values were low. In conclusion, considerable breed differences in PRA and PAC were found in the present study. Further studies are needed to determine if there is an association between developing chronic valvular disease and a high PRA in dogs.

References

Jun 1, 1976·The Journal of Clinical Investigation·L WatkinsA C Barger
Jan 1, 1991·European Journal of Applied Physiology and Occupational Physiology·H C LukaskiW A Siders
Nov 1, 1991·Circulation Research·L B TanK T Weber
Aug 1, 1974·The Journal of Small Animal Practice·J C Whitney
Jan 1, 1970·Cardiovascular Research·A Pomerance, J C Whitney
Jun 1, 1980·Nihon juigaku zasshi. The Japanese journal of veterinary science·K Kogure
Jul 23, 1993·Regulatory Peptides·B BunnemannD Ganten
Nov 6, 1993·BMJ : British Medical Journal·J Poulsen
Jan 1, 1993·The Journal of Audiovisual Media in Medicine·M Nicholls, H Rogers
Jan 1, 1993·Pharmacology & Toxicology·E Poulsen

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Citations

Jun 22, 2010·Journal of Veterinary Internal Medicine·B S ReynoldsH P Lefebvre
Nov 21, 2007·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·E JeunesseH P Lefebvre
Oct 30, 2001·The Veterinary Journal·M BorgarelliJ Häggström
Feb 27, 2019·Journal of Veterinary Internal Medicine·Marisa K AmesBertram Pitt
Jan 29, 1999·Zentralblatt für Veterinärmedizin. Reihe A·H D Pedersen, T Mow
Aug 12, 2018·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Angela E KedgleySpyros D Masouros
Feb 19, 2021·The Journal of Small Animal Practice·J WilshawA Boswood

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