BRENDA, the ELIXIR core data resource in 2021: new developments and updates.

Nucleic Acids Research
Antje ChangDietmar Schomburg

Abstract

The BRENDA enzyme database (https://www.brenda-enzymes.org), established in 1987, has evolved into the main collection of functional enzyme and metabolism data. In 2018, BRENDA was selected as an ELIXIR Core Data Resource. BRENDA provides reliable data, continuous curation and updates of classified enzymes, and the integration of newly discovered enzymes. The main part contains >5 million data for ∼90 000 enzymes from ∼13 000 organisms, manually extracted from ∼157 000 primary literature references, combined with information of text and data mining, data integration, and prediction algorithms. Supplements comprise disease-related data, protein sequences, 3D structures, genome annotations, ligand information, taxonomic, bibliographic, and kinetic data. BRENDA offers an easy access to enzyme information from quick to advanced searches, text- and structured-based queries for enzyme-ligand interactions, word maps, and visualization of enzyme data. The BRENDA Pathway Maps are completely revised and updated for an enhanced interactive and intuitive usability. The new design of the Enzyme Summary Page provides an improved access to each individual enzyme. A new protein structure 3D viewer was integrated. The prediction of the intracel...Continue Reading

References

Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Jul 13, 2000·Journal of Molecular Biology·O EmanuelssonG von Heijne
Sep 9, 2008·Nucleic Acids Research·Andrew G McDonaldKeith F Tipton
Nov 6, 2008·Nucleic Acids Research·Antje ChangDietmar Schomburg
Aug 11, 2011·BMC Bioinformatics·Carola SöhngenDietmar Schomburg
Nov 22, 2011·Nucleic Acids Research·Ulrike WittigWolfgang Müller
Dec 6, 2011·Nucleic Acids Research·Scott Federhen
Apr 17, 2013·BMC Systems Biology·S Alexander RiemerDietmar Schomburg
Oct 29, 2014·Nucleic Acids Research·Ian SillitoeChristine A Orengo
Nov 8, 2014·Nucleic Acids Research·Antje ChangDietmar Schomburg
Oct 2, 2015·Nucleic Acids Research·Carola SöhngenJörg Overmann
Dec 3, 2016·Nucleic Acids Research·Alice R WattamRick L Stevens
Dec 3, 2016·Nucleic Acids Research·Minoru KanehisaKanae Morishima
Dec 5, 2016·Journal of Molecular Biology·John-Marc ChandoniaSteven E Brenner
Dec 8, 2016·Nucleic Acids Research·Sandra PlaczekDietmar Schomburg
Feb 6, 2017·Protein Engineering, Design & Selection : PEDS·S PundirM J Martin
Jul 28, 2017·PloS One·Christian-Alexander DudekDietmar Schomburg
Oct 24, 2017·Nucleic Acids Research·Ron CaspiPeter D Karp
Nov 16, 2017·Nucleic Acids Research·UNKNOWN NCBI Resource Coordinators
Nov 6, 2018·Nucleic Acids Research·Lisa JeskeDietmar Schomburg
Nov 6, 2018·Nucleic Acids Research·UNKNOWN UniProt Consortium
Nov 7, 2018·Nucleic Acids Research·Alex L MitchellRobert D Finn
Jan 18, 2020·Bioinformatics·Rachel DrysdaleJohanna McEntyre

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Citations

Feb 15, 2021·Protein Science : a Publication of the Protein Society·Chelsea J VickersWayne M Patrick
May 1, 2021·Microorganisms·Joao Pedro SaraivaUlisses Nunes da Rocha
May 9, 2021·Nucleic Acids Research·Davide BaldazziRita Casadio
Jul 1, 2021·NPJ Systems Biology and Applications·Alina Renz, Andreas Dräger
Jul 15, 2021·Chemical Science·David KreutterJean-Louis Reymond
Aug 27, 2021·The FEBS Journal·Rossana ZaruMaria J Martin
Sep 25, 2021·Chembiochem : a European Journal of Chemical Biology·Martin PengKersten S Rabe
Sep 17, 2021·Environmental Microbiology·Venkatesh M Ghodke, Narayan S Punekar
Aug 18, 2021·Journal of Integrative Plant Biology·Charles HawkinsSeung Y Rhee
Nov 18, 2021·Proceedings of the National Academy of Sciences of the United States of America·Suhyun KimJang-Cheon Cho

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Software Mentioned

KENDA
Open Science
ELIXIR
BREPS
EnzymeDetector
FRENDA
NGL viewer
TrEMBL
KEGG
CAVEman

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