Breviscapine protects against cardiac hypertrophy through blocking PKC-alpha-dependent signaling

Journal of Cellular Biochemistry
Ling YanHong-Liang Li

Abstract

Breviscapine is a mixture of flavonoid glycosides extracted from the Chinese herbs. Previous studies have shown that breviscapine possesses comprehensive pharmacological functions. However, very little is known about whether breviscapine have protective role on cardiac hypertrophy. The aim of the present study was to determine whether breviscapine attenuates cardiac hypertrophy induced by angiotensin II (Ang II) in cultured neonatal rat cardiac myocytes in vitro and pressure-overload-induced cardiac hypertrophy in mice in vivo. Our data demonstrated that breviscapine (2.5-15 microM) dose-dependently blocked cardiac hypertrophy induced by Ang II (1 microM) in vitro. The results further revealed that breviscapine (50 mg/kg/day) prevented cardiac hypertrophy induced by aortic banding as assessed by heart weight/body weight and lung weight/body weight ratios, echocardiographic parameters, and gene expression of hypertrophic markers. The inhibitory effect of breviscapine on cardiac hypertrophy is mediated by disrupting PKC-alpha-dependent ERK1/2 and PI3K/AKT signaling. Further studies showed that breviscapine inhibited inflammation by blocking NF-kappaB signaling, and attenuated fibrosis and collagen synthesis through abrogating Sma...Continue Reading

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Citations

Dec 21, 2011·Cardiovascular Drugs and Therapy·Ting HeMan-Wen Jin
Jun 5, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Mariane AbdillahiRavichandran Ramasamy
May 31, 2013·Journal of Molecular Histology·Wei DengQizhu Tang
May 3, 2019·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Junrong LongJun Yang
Jun 8, 2017·Frontiers in Pharmacology·Jialiang GaoJie Wang

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