Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge.

EBioMedicine
Martin S WinklerMarcin F Osuchowski

Abstract

Many milestones in medical history rest on animal modeling of human diseases. The SARS-CoV-2 pandemic has evoked a tremendous investigative effort primarily centered on clinical studies. However, several animal SARS-CoV-2/COVID-19 models have been developed and pre-clinical findings aimed at supporting clinical evidence rapidly emerge. In this review, we characterize the existing animal models exposing their relevance and limitations as well as outline their utility in COVID-19 drug and vaccine development. Concurrently, we summarize the status of clinical trial research and discuss the novel tactics utilized in the largest multi-center trials aiming to accelerate generation of reliable results that may subsequently shape COVID-19 clinical treatment practices. We also highlight areas of improvement for animal studies in order to elevate their translational utility. In pandemics, to optimize the use of strained resources in a short time-frame, optimizing and strengthening the synergy between the preclinical and clinical domains is pivotal.

References

Aug 1, 1990·American Journal of Respiratory Cell and Molecular Biology·R Pabst, I Gehrke
Dec 2, 2004·Nature Reviews. Immunology·Bart O RoepMatthias von Herrath
Oct 13, 2006·JAMA : the Journal of the American Medical Association·Daniel G Hackam, Donald A Redelmeier
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fumihiko YasuiMichinori Kohara
Dec 24, 2009·Critical Care Medicine·Deborah CookJohn Marshall
Jun 15, 2011·Influenza and Other Respiratory Viruses·Judith D EasterbrookJeffery K Taubenberger
Feb 27, 2014·Shock·Marcin F OsuchowskiIrshad H Chaudry
Jul 19, 2014·Nephron. Experimental Nephrology·Boris Betz, Bryan R Conway
Jun 3, 2015·Journal of Leukocyte Biology·Philip A EfronLyle L Moldawer
Oct 4, 2015·Biochemical Pharmacology·Aileen King, James Bowe
Sep 15, 2016·Stroke; a Journal of Cerebral Circulation·Farhaan VahidyJaroslaw Aronowski
Dec 19, 2016·BMC Medicine·Amanda M Rojek, Peter W Horby
Dec 31, 2016·Epilepsy Research·Niina LapinlampiAsla Pitkänen
Apr 5, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rudragouda ChannappanavarStanley Perlman
Jun 8, 2018·Shock·Daniel G RemickMarcin F Osuchowski
Jul 7, 2018·Critical Care Medicine·Bram RochwergGordon Guyatt
Nov 15, 2018·Frontiers in Immunology·Miriam Kesselmeier, André Scherag
Jan 31, 2019·Lancet·Annelies Wilder-SmithBridget Wills
Jun 12, 2019·Annals of Intensive Care·Antoine GuillonUNKNOWN Translational Research Committee of the French Intensive Care Society (Société de Réanimation de Langue Française)
Nov 26, 2019·Seminars in Cell & Developmental Biology·Maria C Basil, Edward E Morrisey
Jan 1, 2020·The Journal of Infectious Diseases·Eleonora CiarloThierry Roger
Mar 3, 2020·The Lancet Infectious Diseases·Justin StebbingPeter Richardson
Apr 8, 2020·Cell Host & Microbe·Young-Il KimYoung Ki Choi
Apr 23, 2020·Animal Models and Experimental Medicine·Pin YuChuan Qin
Apr 25, 2020·Science·Alex John London, Jonathan Kimmelman
Apr 29, 2020·The European Respiratory Journal·David M G HalpinRuth M Hadfield

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