Bridging Anxiety and Depression: A Network Approach in Anxious Adolescents.

Journal of Affective Disorders
Eric T DobsonJeffrey R Strawn

Abstract

The phenomenology and neurobiology of depressive symptoms in anxious youth is poorly understood. Association networks of anxiety and depressive symptoms were developed in adolescents with generalized anxiety disorder (GAD; N=52, mean age: 15.4±1.6 years) who had not yet developed major depressive disorder. Community analyses were used to create consensus clusters of depressive and anxiety symptoms and to identify "bridge" symptoms between the clusters. In a subset of this sample (n=39), correlations between cortical thickness and depressive symptom severity was examined. Ten symptoms clustered into an anxious community, 5 clustered into a depressive community and 5 bridged the two communities: impaired schoolwork, excessive weeping, low self-esteem, disturbed appetite, and physical symptoms of depression. Patients with more depressive cluster burden had altered cortical thickness in prefrontal, inferior and medial parietal (e.g., precuneus, supramarginal) regions and had decreases in cortical thickness-age relationships in prefrontal, temporal and parietal cortices. Data are cross-sectional and observational. Limited sample size precluded secondary analysis of comorbidities and demographics. In youth with GAD, a sub-set of symp...Continue Reading

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