Bridging the dynamics and organization of chromatin domains by mathematical modeling

BioRxiv : the Preprint Server for Biology
Soya ShinkaiYuichi Togashi

Abstract

The genome is three-dimensionally organized in the cell, and the mammalian genome DNA is partitioned into submegabase-sized chromatin domains. Genome functions are regulated within and across the domains according to their organization, whereas the chromatin itself is highly dynamic. However, the details of such dynamic organization of chromatin domains in living cells remain unclear. To unify chromatin dynamics and organization, we recently demonstrated that structural information of chromatin domains in living human cells can be extracted from analyses of the subdiffusive nucleosome movement using mathematical modeling. Our mathematical analysis suggested that as the chromatin domain becomes smaller and more compact, nucleosome movement becomes increasingly restricted. Here, we show the implication of these results for bridging the gap between chromatin dynamics and organization, and provide physical insight into chromatin domains as efficient units to conduct genome functions in the thermal noisy environment of the cell.

Related Concepts

Nucleosomes
Genome
Environment
Nucleosome Location
Human Cell Line
Gene Function
Structure
Cellular Component Organization
Chromatin Location
Analysis

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