Bridging the gap between host immune response and intestinal dysbiosis in inflammatory bowel disease: does immunoglobulin A mark the spot?

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Jason M ShapiroNeal S LeLeiko

Abstract

Inflammatory bowel disease (IBD) is a chronic, debilitating condition characterized by relapsing and remitting episodes of gastrointestinal inflammation. As the incidence and prevalence have increased, so has our understanding of the pathophysiology of this complex, immunologically mediated disease. With advances in bacterial and human gene sequencing technologies, a significant amount of work has focused on how alterations in the intestinal microbiome affect disease onset and progression. A recent study in Cell suggests that it may be possible to identify specific bacteria responsible for promoting a proinflammatory state by assessing the degree to which they are coated by the immunoglobulin (Ig) A. A combination of antibody-based bacterial cell sorting, flow cytometry, and 16s ribosomal RNA gene sequencing was used to identify IgA-coated bacteria from stool of specific pathogen-free mice. This technique was used to demonstrate that IgA-coated bacteria were indeed detectable and increased in a mouse model of colitis. Stool from patients with IBD was then used to generate 2 groups of IgA+ and IgA- bacterial consortia. When transplanted into specific pathogen-free mice, no initial clinical differences were noted. However, when m...Continue Reading

References

Oct 7, 2011·Mucosal Immunology·N J MantisB Corthésy
May 9, 2012·Frontiers in Immunology·Emma SlackSiegfried Hapfelmeier
Oct 30, 2012·Nature Reviews. Immunology·Oliver Pabst
Mar 19, 2014·Cell Host & Microbe·Dirk GeversRamnik J Xavier

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Citations

Aug 19, 2015·Gastroenterology·Marla Dubinsky, Jonathan Braun
Mar 13, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Joana TorresJean-Frédéric Colombel
Aug 18, 2016·Frontiers in Immunology·Abigail BassonFabio Cominelli
Jan 2, 2021·Cell Host & Microbe·Jason M ShapiroJ C Clemente

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