Bridging the Gap Between Science and Clinical Efficacy: Physiology, Imaging, and Modeling of Aerosols in the Lung

Journal of Aerosol Medicine and Pulmonary Drug Delivery
Chantal DarquenneOtmar Schmid

Abstract

Development of a new drug for the treatment of lung disease is a complex and time consuming process involving numerous disciplines of basic and applied sciences. During the 2015 Congress of the International Society for Aerosols in Medicine, a group of experts including aerosol scientists, physiologists, modelers, imagers, and clinicians participated in a workshop aiming at bridging the gap between basic research and clinical efficacy of inhaled drugs. This publication summarizes the current consensus on the topic. It begins with a short description of basic concepts of aerosol transport and a discussion on targeting strategies of inhaled aerosols to the lungs. It is followed by a description of both computational and biological lung models, and the use of imaging techniques to determine aerosol deposition distribution (ADD) in the lung. Finally, the importance of ADD to clinical efficacy is discussed. Several gaps were identified between basic science and clinical efficacy. One gap between scientific research aimed at predicting, controlling, and measuring ADD and the clinical use of inhaled aerosols is the considerable challenge of obtaining, in a single study, accurate information describing the optimal lung regions to be ta...Continue Reading

References

Jul 1, 1989·Experimental Lung Research·M SvartengrenP Camner
Jun 1, 1989·The American Review of Respiratory Disease·P R PhippsS D Anderson
Jan 1, 1982·The Annals of Occupational Hygiene·D L SwiftW Mitzner
Jun 1, 1980·American Industrial Hygiene Association Journal·T L Chan, M Lippmann
Mar 1, 1993·The American Review of Respiratory Disease·M AndersonP Camner
Mar 1, 1997·Journal of Applied Physiology·H T RobertsonD Covert
May 27, 1999·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·W H Finlay
Jul 17, 1999·The American Journal of Physiology·N E VlahakisR D Hubmayr
Nov 7, 2000·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·J S FlemingT B Martonen
Jun 27, 2001·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·M B Dolovich
May 7, 2002·American Journal of Respiratory and Critical Care Medicine·John P KressJesse B Hall
Jun 19, 2002·Pharmaceutical Research·Sarma P DudduJeffry G Weers
Aug 20, 2002·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·William D BennettKnut Sommerer
May 10, 2003·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·J S FlemingS T Holgate
Aug 5, 2003·Journal of Applied Physiology·Omar S UsmaniPeter J Barnes
Jan 1, 1956·Journal of Applied Physiology·A B OTISE P RADFORD
Nov 18, 2003·British Journal of Clinical Pharmacology·N R Labiris, M B Dolovich
Sep 15, 2004·International Journal of Pharmaceutics·R DalbyT Voshaar
Jan 1, 2005·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Chantal Darquenne, G Kim Prisk
Mar 18, 2005·Nature·Jose G VenegasR Scott Harris
Jun 1, 2005·Respiratory Physiology & Neurobiology·Ewald R WeibelMarcel Filoche
Sep 30, 2005·American Journal of Respiratory and Critical Care Medicine·Omar S UsmaniPeter J Barnes
Dec 29, 2005·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Mark DeLongCraig Dunbar
Jan 2, 2007·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Lars BorgströmLars Thorsson
Feb 3, 2007·American Journal of Respiratory Cell and Molecular Biology·Fabian BlankPeter Gehr
Mar 29, 2007·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Andrew R ClarkCarlos Schuler
Sep 27, 2007·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Patricia K P BurnellIan Shrubb
Dec 18, 2007·Respiratory Medicine·Federico LavoriniGraham K Crompton
May 27, 2008·Journal of Biomechanics·T GemciR Collins
Jun 3, 2008·The European Respiratory Journal·S Lahzami, G G King
Jun 4, 2008·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Jonathan B PetersonChantal Darquenne
Jun 4, 2008·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Warren H Finlay, Andrew R Martin
Jul 26, 2008·Nature Nanotechnology·Petra DamesCarsten Rudolph
Sep 2, 2008·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Kim SeltingRajiv Dhand
Dec 17, 2008·Annals of Biomedical Engineering·Baoshun Ma, Kenneth R Lutchen
Feb 12, 2009·Therapeutics and Clinical Risk Management·Gabriele NicoliniLeonardo M Fabbri

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Citations

Jun 9, 2016·Expert Opinion on Drug Delivery·Michal Pirozynski, Tomasz R Sosnowski
Jul 9, 2016·Respiratory Research·Sophie PerinelJérémie Pourchez
Dec 16, 2016·Drug Development and Industrial Pharmacy·Stefano GiovagnoliMaurizio Ricci
Jul 7, 2017·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Otmar SchmidBarbara Rothen-Rutishauser
Feb 17, 2018·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Warren M ZapolIra Katz
Sep 7, 2018·Breathe·Martyn F Biddiscombe, Omar S Usmani
Apr 4, 2019·Medical Sciences : Open Access Journal·Jose R Jardim, Oliver A Nascimento
Mar 5, 2020·Expert Opinion on Drug Delivery·Arbel Artzy-SchnirmanJosué Sznitman
Jul 18, 2020·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Emily L KoleweCatherine A Fromen
Apr 20, 2018·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Luciana AlcoforadoJose G Venegas
Nov 6, 2018·Expert Opinion on Drug Delivery·Andrew R MartinWarren H Finlay
Nov 14, 2019·International Journal of Environmental Research and Public Health·Lin ZangYu Zhang
Dec 15, 2019·Animals : an Open Access Journal From MDPI·Jinxiang XiRichard Corley
May 14, 2020·Journal of Personalized Medicine·Sean D McCarthyBrendan D Higgins
Nov 25, 2020·Drug Discovery Today·Carlos Victor Montefusco-PereiraClaus-Michael Lehr
Jan 28, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Omar S UsmaniWilfried De Backer
Feb 2, 2021·Medical Devices : Evidence and Research·Geert-Jan van GeffenJörgen Bruhn
Oct 16, 2020·Biotechnology and Bioengineering·Daniele CeiOtmar Schmid
Jul 1, 2020·Delaware Journal of Public Health·Catherine A Fromen, Jason P Gleghorn

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BETA
imaging techniques

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ALICE
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