Brief alteration in dopaminergic function during development causes deficits in adult reproductive behavior

Journal of Neurobiology
C F Harding

Abstract

Our previous research revealed dramatic increases in dopaminergic function in vocal control and auditory nuclei in male zebra finches during the period of song learning. Such increases were not seen in the hypothalamic areas examined. In the current study, we manipulated dopamine receptor function during this period to determine how this might affect later singing behavior. Males were implanted with osmotic minipumps providing 0, 0.5, or 5 microg/g/day of the mixed D1/D2 dopamine receptor antagonist cis-flupenthixol from day 45 until day 57. At approximately 86 days of age, males were given subcutaneous silastic implants containing a maintenance dose of androgen, in case antagonist treatment interfered with adult androgen secretion. One week later, they began a series of three weekly tests to determine if this early treatment affected courtship singing. Males treated with the low dose of cis-flupenthixol showed profound decrements in courtship singing and copulatory behavior. Unlike saline-treated controls, low-dose males sang to females infrequently. High-intensity courtship displays in which males dance towards females while singing were most affected. Despite their decreased courtship singing, low-dose males were interested ...Continue Reading

References

Feb 1, 1975·The Journal of Experimental Zoology·A P Arnold
Jan 1, 1990·Developmental Pharmacology and Therapeutics·G J BoerM Mirmiran
Jan 1, 1990·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M MirmiranD Van der Werf
Feb 1, 1990·Pharmacology, Biochemistry, and Behavior·A Agmo, Z Picker
Jul 1, 1989·Journal of Neuroscience Research·C R Dermon, E D Kouvelas
Mar 1, 1983·Hormones and Behavior·C F HardingM J Walters
Feb 20, 1981·The Journal of Comparative Neurology·J W LewisL L Butcher
Apr 1, 1996·Pharmacology, Biochemistry, and Behavior·K E StevensG M Rose
Oct 1, 1996·Pharmacology, Biochemistry, and Behavior·A AgmoJ L Contreras
Sep 23, 1997·Pharmacology, Biochemistry, and Behavior·C CastagnaJ Balthazart
Nov 10, 1998·Neuron·E D JarvisF Nottebohm
Mar 11, 1999·Current Opinion in Neurobiology·R Mooney
Dec 20, 1999·Behavioural Brain Research·E M HullJ Moses
Mar 10, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·F I Tarazi, R J Baldessarini
Sep 11, 2001·Psychopharmacology·N M de BruinB A Ellenbroek
May 9, 2002·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Jacques BalthazartGregory F Ball

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Citations

Oct 20, 2007·Behavioural Brain Research·Sharon RauceoElizabeth Rodriguez
Jan 9, 2010·The Journal of Comparative Neurology·Lubica KubikovaErich D Jarvis
Oct 10, 2006·Neuroscience·I S Bharati, J L Goodson

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