PMID: 16520475Mar 8, 2006Paper

Brief communication: fatal human metapneumovirus infection in stem-cell transplant recipients

Annals of Internal Medicine
Janet A EnglundLawrence Corey

Abstract

Human metapneumovirus (hMPV), a recently discovered respiratory virus, is associated with clinical disease in young and elderly persons. To determine the importance of hMPV in hematopoietic stem-cell transplant recipients. Retrospective survey of patients with consecutive residual bronchoalveolar lavage (BAL) samples. Referral cancer center. Hematopoietic stem-cell transplant recipients who underwent BAL because of lower respiratory tract disease. Bronchoalveolar lavage specimens were assayed by quantitative real-time polymerase chain reaction methods. Human metapneumovirus was detected in BAL specimens from 5 of 163 patients (3.0%). Persistent viral infection was noted in 3 patients with several samples, and hMPV was detected in 1 of 2 lung specimens tested. Infected patients became symptomatic within the first 40 days after transplantation. Initial symptoms included fever, cough, nasal congestion, and sore throat. Clinical findings included respiratory failure, pulmonary hemorrhage, and culture-negative septic shock. Four of 5 patients died with acute respiratory failure. This retrospective study did not evaluate asymptomatic patients or those with mild disease. Human metapneumovirus infection in the lower respiratory tract i...Continue Reading

Citations

Dec 10, 2008·Archives of Internal Medicine·Edward E WalshAnn R Falsey
Sep 13, 2012·Current Infectious Disease Reports·Defne Arslan, Lara Danziger-Isakov
Aug 19, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Kashif RazaShahid Husain
Feb 15, 2013·The New England Journal of Medicine·Kathryn M EdwardsUNKNOWN New Vaccine Surveillance Network
May 8, 2010·The Journal of Infectious Diseases·John V WilliamsJames E Crowe
Oct 2, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hans H HirschPer Ljungman
Oct 23, 2008·The Pediatric Infectious Disease Journal·Ann R Falsey
Oct 4, 2008·The Pediatric Infectious Disease Journal·Minna KoskenvuoOlli Ruuskanen
Sep 5, 2009·The Pediatric Infectious Disease Journal·Sean X ZhangSusan E Richardson
May 16, 2009·Pediatric Emergency Care·Holly Brodzinski, Richard M Ruddy
Oct 31, 2007·Antimicrobial Agents and Chemotherapy·Céline DeffrasnesGuy Boivin
Oct 7, 2011·Clinical Microbiology Reviews·Verena SchildgenOliver Schildgen
Apr 11, 2008·Clinical Microbiology Reviews·W Garrett NicholsMichael Boeckh
May 15, 2007·Journal of Clinical Microbiology·Charles Y ChiuJoseph L DeRisi
Dec 13, 2006·American Journal of Respiratory and Critical Care Medicine·Marc B Hershenson, Sebastian L Johnston
May 3, 2011·American Journal of Respiratory and Critical Care Medicine·Angela Panoskaltsis-MortariUNKNOWN American Thoracic Society Committee on Idiopathic Pneumonia Syndrome
Sep 11, 2009·Virology Journal·Chin-Fen YangJohn V Williams
Dec 4, 2013·Pediatrics in Review·Jennifer E Schuster, John V Williams
Dec 21, 2006·Emerging Infectious Diseases·Bernd KupferOliver Schildgen
Apr 29, 2008·Emerging Infectious Diseases·Yacine Abed, Guy Boivin
Jan 10, 2013·Viruses·Lenneke E M HaasKaren A Heemstra
Jan 18, 2013·Viruses·Reagan G Cox, John V Williams
Nov 25, 2014·Journal of the Pediatric Infectious Diseases Society·Helen Y ChuJanet A Englund
Oct 30, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Roy F ChemalyMichael J Boeckh
Jul 1, 2015·Leukemia & Lymphoma·Alexander HoelleinKatharina Götze
Feb 6, 2010·Expert Opinion on Biological Therapy·Ann M LeenCliona M Rooney
Sep 17, 2011·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Luke O'ShaughnessySean Doyle
Aug 27, 2011·Clinics in Chest Medicine·Kathryn A Radigan, Richard G Wunderink
Jul 5, 2011·Paediatric Respiratory Reviews·T Nicolai
Aug 3, 2010·Infectious Disease Clinics of North America·Shawn P E NishiSteve Duncan
May 15, 2010·Infectious Disease Clinics of North America·Deepali Kumar, Atul Humar
Apr 13, 2010·Virus Research·Sharon J TollefsonJohn V Williams

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