Brief, meal-contingent infusions of gastrin-releasing peptide1-27 and neuromedin B-10 inhibit spontaneous feeding in rats

Physiology & Behavior
P A RushingN Geary

Abstract

We have previously shown that brief, meal-contingent infusions of the amphibian peptide bombesin (BN) reduce meal size in spontaneously feeding rats. These inhibitory effects presumably reflect actions of BN on receptors for its mammalian homologues, which include gastrin-releasing peptide1-27 (GRP) and neuromedin B-10 (NMB). In the present study, we used the spontaneous feeding paradigm to explore the effects of meal-contingent infusions of these mammalian homologues. Undisturbed, ad lib-fed male rats (n = 12) with chronic inferior vena caval catheters were infused with saline, 5 nmol/kg GRP, 5 nmol/kg NMB, and a mixture of 5 nmol/kg GRP and 5 nmol/kg NMB in counterbalanced order, with intervening noninfusion days. Infusions were remotely activated at the onset of the first nocturnal meal and continued for 3 min (34 microliters/min), delivery being completed within the first 2 min of infusion. Feeding was measured via electronic balances linked to a computer. The effects of all peptide conditions were confined to the first nocturnal meal. Significant and comparable decreases in the size and duration of this meal were observed with GRP, NMB, and GRP + NMB, with no significant effects on the intermeal interval or satiety ratio (...Continue Reading

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Citations

May 15, 2002·European Journal of Pharmacology·Kazuyuki YamadaKeiji Wada
Feb 6, 2004·Psychological Review·Jan H Strubbe, Stephen C Woods
Sep 21, 2000·The Proceedings of the Nutrition Society·G A Bray
Jan 10, 2012·Peptides·Jizette V HuntAyman I Sayegh
Dec 22, 1999·Endocrine Reviews·G A Bray, F L Greenway
Dec 9, 2004·The American Journal of Clinical Nutrition·Luigi BouchardLouis Pérusse
Feb 5, 2000·Neuropeptides·Z MeraliH Anisman
Jan 6, 2005·Gastroenterology·April D Strader, Stephen C Woods

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