Brief Report: A Gene Enrichment Approach Applied to Sleep and Autism.

Journal of Autism and Developmental Disorders
Emily A AbelKristine Marceau

Abstract

Sleep disorders (SD) are common in autism spectrum disorder (ASD), yet relatively little is known about the potential genetic mechanisms involved in SD and ASD comorbidity. The current study begins to fill this gap with a gene enrichment study that (1) identifies risk genes that contribute to both SD and ASD which implicate circadian entrainment, melatonin synthesis, and several genetic syndromes. An over-representation analysis identified several enriched pathways that suggest dopamine and serotonin synapses as potential shared SD and ASD mechanisms. This overlapping gene set and the highlighted biological pathways may serve as a preliminary stepping-stone for new genetic investigations of SD and ASD comorbidity.

References

Feb 23, 2000·Neuroreport·R GodboutL Mottron
Oct 18, 2003·BMC Psychiatry·Pekka TaniTarja Porkka-Heiskanen
Aug 5, 2004·Neuropsychobiology·Pekka TaniTarja Porkka-Heiskanen
Feb 12, 2005·Brain : a Journal of Neurology·Elyse LimogesRoger Godbout
Feb 23, 2008·Journal of Autism and Developmental Disorders·Hiie AllikHans Smedje
Oct 23, 2008·Nucleic Acids Research·Atanas KamburovRalf Herwig
Apr 29, 2009·Sleep Medicine Reviews·Amanda L Richdale, Kimberly A Schreck
Jul 8, 2010·Sleep Medicine·Flavia CortesiKyle Johnson
Nov 13, 2010·Nucleic Acids Research·Atanas KamburovRalf Herwig
Dec 6, 2011·Nucleic Acids Research·Li-Ming XuLiping Wei
May 11, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nora D VolkowSergi Ferré
Oct 17, 2013·International Journal of Molecular Sciences·Sylvie TordjmanJulie Vernay-Leconte
Jun 19, 2014·Human Molecular Genetics·Iakes EzkurdiaMichael L Tress
Jul 26, 2014·Journal of Autism and Developmental Disorders·Olivia J VeatchBeth A Malow
Dec 3, 2014·Genomics, Proteomics & Bioinformatics·Lv JinShao-Qi Rao
Nov 19, 2015·Neuroscience·C L MullerJ Veenstra-VanderWeele
Feb 6, 2017·Journal of Autism and Developmental Disorders·Emma K Baker, Amanda L Richdale
May 16, 2017·Current Psychiatry Reports·Margaret C SoudersJennifer Pinto-Martin
Jul 28, 2017·Developmental Neuroscience·Denis Pavăl
May 29, 2018·Neuroscience and Biobehavioral Reviews·Kristine Marceau, Emily A Abel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Related Papers

Autism : the International Journal of Research and Practice
Dermot Bowler
Autism : the International Journal of Research and Practice
Sven Bölte
The Journal of the South Carolina Medical Association
Laura A Carpenter, Michelle M Macias
© 2022 Meta ULC. All rights reserved