Abstract
Elevated laughing and smiling is a key characteristic of the Angelman syndrome behavioral phenotype, with cross-sectional studies reporting changes with environment and age. This study compares levels of laughing and smiling in 12 participants across three experimental conditions [full social interaction (with eye contact), social interaction with no eye contact, proximity only] at two data points. No differences were noted in frequency of laughing and smiling over time in any condition. However, with age as a covariate, the frequency of laughing and smiling decreased over time in the full social interaction (with eye contact) condition only. As this is the first longitudinal study to explore these behaviors in Angelman syndrome, the results suggest a gene-environment-time interaction within the behavioral phenotype.
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Citations
Apr 13, 2018·Case Reports in Ophthalmology·Yurie FukiyamaTsunehiko Ikeda
Oct 26, 2018·Orphanet Journal of Rare Diseases·Dawn AdamsChris Oliver
May 26, 2020·American Journal of Medical Genetics. Part a·Dawn AdamsHelen Heussler
Oct 19, 2017·Orphanet Journal of Rare Diseases·Anne C WheelerRaquel Cabo
Dec 13, 2019·Journal of Intellectual Disability Research : JIDR·M HealdC Oliver
Oct 10, 2018·Frontiers in Psychology·Darren David Chadwick, Tracey Platt
Apr 20, 2018·American Journal on Intellectual and Developmental Disabilities·Dawn AdamsChris Oliver
Oct 4, 2020·Scientific Reports·Serena MichelettiElisa Fazzi