Brief Report: A Longitudinal Study of Excessive Smiling and Laughing in Children with Angelman Syndrome

Journal of Autism and Developmental Disorders
Dawn AdamsChris Oliver

Abstract

Elevated laughing and smiling is a key characteristic of the Angelman syndrome behavioral phenotype, with cross-sectional studies reporting changes with environment and age. This study compares levels of laughing and smiling in 12 participants across three experimental conditions [full social interaction (with eye contact), social interaction with no eye contact, proximity only] at two data points. No differences were noted in frequency of laughing and smiling over time in any condition. However, with age as a covariate, the frequency of laughing and smiling decreased over time in the full social interaction (with eye contact) condition only. As this is the first longitudinal study to explore these behaviors in Angelman syndrome, the results suggest a gene-environment-time interaction within the behavioral phenotype.

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May 14, 2011·American Journal of Medical Genetics. Part a·Dawn AdamsChris Oliver

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Citations

Apr 13, 2018·Case Reports in Ophthalmology·Yurie FukiyamaTsunehiko Ikeda
May 26, 2020·American Journal of Medical Genetics. Part a·Dawn AdamsHelen Heussler
Oct 19, 2017·Orphanet Journal of Rare Diseases·Anne C WheelerRaquel Cabo
Dec 13, 2019·Journal of Intellectual Disability Research : JIDR·M HealdC Oliver
Oct 4, 2020·Scientific Reports·Serena MichelettiElisa Fazzi

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Angelman Syndrome

Angelman syndrome is a neurogenetic imprinting disorder caused by loss of the maternally inherited UBE3A gene and is characterized by generalized epilepsy, limited expressive speech, sleep dysfunction, and movement disorders. Here is the latest research.

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