Nov 13, 2019

Brief Report: Adipogenic Expression of Brown Fat Genes in HIV and HIV-Related Parameters

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Suman SrinivasaSteven K Grinspoon

Abstract

Persons with HIV are at increased risk for adipose dysfunction, which could mediate metabolic complications such as cardiovascular disease, fatty liver disease, and diabetes. We have previously reported reduced browning and beiging capacity of the subcutaneous adipose depot in HIV. We sought to evaluate how HIV-related parameters are related to the expression of brown and beige fat genes in the abdominal subcutaneous adipose tissue. Eighteen persons with HIV underwent punch biopsy of abdominal subcutaneous fat to determine mRNA expression of adipose-related genes using quantitative reverse transcriptase-polymerase chain reaction. Duration of antiretroviral therapy use, particularly related to protease inhibitor use, was significantly related to reduced expression of multiple brown and beige fat genes (including UCP1, PGC1α, PRDM16 and others, all P ≤ 0.04) in the abdominal subcutaneous fat. In addition, duration of HIV and CD4 T-cell count were significantly correlated with reduced expression of multiple brown and beige fat genes in the abdominal subcutaneous fat (PGC1α, P2XR5, TMEM26, CD137, all P ≤ 0.05 for duration of HIV; and PGC1α, ZIC1, PRDM16, PAT2, P2RX5, TMEM26, CD137, all P ≤ 0.04). In contrast, HIV viral load did not...Continue Reading

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Mentioned in this Paper

Virus
Fatty Liver
brown adipose tissue uncoupling protein
Antiretroviral Therapy
HIV Infections
Persons
TMEM26 protein, human
Evaluation
Cardiovascular Diseases
Quantitative Reverse Transcriptase PCR

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