Brief Report: Arthritis in KRN T Cell Receptor-Transgenic Mice Does Not Require Interleukin-17 or Th17 Cells

Arthritis & Rheumatology
Jennifer L AugerBryce A Binstadt

Abstract

Th17 cells and interleukin-17 (IL-17) cytokine family members are implicated in the pathogenesis of many rheumatic diseases. Most studies in mouse models of inflammatory arthritis have demonstrated a key role for the proinflammatory cytokine IL-17A and its receptor, the IL-17 receptor (IL-17R) A/C heterodimer. The aim of this study was to use a rigorous genetic approach to evaluate the contribution of Th17 cells and IL-17 in the autoantibody-dependent KRN T cell receptor-transgenic mouse model of arthritis. We bred KRN mice expressing the major histocompatibility complex class II molecule A(g7) (referred to as K/B/g7 mice) and genetically lacking the related cytokines IL-17A and IL-17F or their critical receptor subunit, IL-17RA. Using bone marrow transplantation, we generated mice in which hematopoietic cells from K/B/g7 donor mice lacked the key Th17-differentiating transcription factor, retinoic acid receptor-related orphan nuclear receptor γt (Rorγt). K/B/g7 mice lacking both IL-17A and IL-17F produced normal titers of pathogenic autoantibodies, and arthritis developed in a typical manner. Similarly, neither IL-17RA nor Rorγt expression by hematopoietic cells was required for disease development in this model. Despite prior...Continue Reading

References

Nov 29, 1996·Cell·V KouskoffD Mathis
Jun 4, 2005·Arthritis and Rheumatism·Koichiro OhmuraChristophe Benoist
Dec 28, 2007·Infection and Immunity·Melissa BarmanNita Salzman
Jul 4, 2009·Nature Reviews. Immunology·Sarah L Gaffen
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Bryce A BinstadtDiane Mathis
Oct 20, 2009·Cell·Ivaylo I IvanovDan R Littman
Oct 27, 2011·PloS One·Christian D SadikAndrew D Luster
Aug 21, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katharine E Block, Haochu Huang
May 13, 2014·Clinical and Experimental Immunology·S SarkarS R Bommireddy
Aug 26, 2014·Nature Reviews. Immunology·Sarah L GaffenDaniel J Cua
Apr 25, 2015·Nature Reviews. Rheumatology·Erik Lubberts

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Citations

Sep 21, 2018·Frontiers in Immunology·Georges AbboudLaurence Morel
Mar 30, 2017·Seminars in Immunopathology·Natacha BessisMarie-Christophe Boissier
Jul 30, 2017·Journal of Clinical Medicine·Motomu Hashimoto
Mar 10, 2020·Neuroscience and Biobehavioral Reviews·Rafael González-CanoEnrique J Cobos

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