Brief Report: Cartilage Thickness Change as an Imaging Biomarker of Knee Osteoarthritis Progression: Data From the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium

Arthritis & Rheumatology
Felix EcksteinFNIH OA Biomarkers Consortium

Abstract

To investigate the association of cartilage thickness change over 24 months, as determined by magnetic resonance imaging (MRI), with knee osteoarthritis (OA) progression at 24-48 months. This nested case-control study included 600 knees with a baseline Kellgren/Lawrence (K/L) grade of 1-3 from 600 Osteoarthritis Initiative (OAI) participants. Case knees (n = 194) had both medial tibiofemoral radiographic joint space loss (≥0.7 mm) and a persistent increase in the Western Ontario and McMaster Universities Osteoarthritis Index pain score (≥9 on a 0-100 scale) 24-48 months from baseline. Control knees (n = 406) included 200 with neither radiographic nor pain progression, 103 with radiographic progression only, and 103 with pain progression only. Medial and lateral femorotibial cartilage was segmented from sagittal 3T MRIs at baseline, 12 months, and 24 months. Logistic regression was used to assess the association of change in cartilage thickness, with a focus on the central medial femorotibial compartment, and OA progression. Central medial femorotibial compartment thickness loss was significantly associated with case status, with an odds ratio (OR) of 1.9 (95% confidence interval [95% CI] 1.6-2.3) (P < 0.0001). Association with ...Continue Reading

Associated Clinical Trials

References

Feb 24, 2009·Osteoarthritis and Cartilage·P OrnettiM Dougados
Jun 26, 2012·Annals of the Rheumatic Diseases·Felix EcksteinUNKNOWN OAI investigators
Jul 12, 2012·Nature Reviews. Rheumatology·Felix EcksteinMichael C Nevitt
Dec 4, 2012·Arthritis Care & Research·Elena LosinaJeffrey N Katz
May 6, 2014·Best Practice & Research. Clinical Rheumatology·David J HunterVirginia Kraus
Oct 4, 2014·Osteoarthritis and Cartilage·F EcksteinC G Miller

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Citations

Dec 10, 2015·Frontiers in Physiology·Rebecca Lewis, Richard Barrett-Jolley
Jun 3, 2016·Journal of Magnetic Resonance Imaging : JMRI·Jennifer S GregoryRichard M Aspden
Jan 23, 2016·Annals of Physical and Rehabilitation Medicine·D HayashiA Guermazi
Oct 11, 2017·Medicine and Science in Sports and Exercise·Derek N PamukoffMichael N Vakula
Jul 7, 2017·SLAS Discovery·David A Walsh, Joanne Stocks
Jul 22, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ashley A WilliamsConstance R Chu
Oct 3, 2018·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Valentina Pedoia, Sharmila Majumdar
Jul 19, 2019·Journal of Exercise Rehabilitation·Sang-Cheol Im, Kyoung Kim
May 25, 2020·Journal of Magnetic Resonance Imaging : JMRI·James W MacKayFiona J Gilbert
Oct 19, 2016·Current Opinion in Rheumatology·Win M OoDavid J Hunter
May 10, 2020·Annals of the Rheumatic Diseases·Kathryn BaconDavid Felson
Aug 23, 2019·The British Journal of Radiology·Teodoro Martín NoguerolAntonio Luna
Jan 23, 2020·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Jonathan S PalmerAndrew J Price
Nov 23, 2019·Journal of Magnetic Resonance Imaging : JMRI·Akshay S ChaudhariBrian A Hargreaves
Sep 9, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Claudia IriondoValentina Pedoia
Oct 9, 2020·Annals of the Rheumatic Diseases·Xiang-Dong WuGui-Xing Qiu
Jan 9, 2021·Osteoarthritis and Cartilage·F EcksteinA G Culvenor
Jul 9, 2021·Radiology. Artificial Intelligence·Arjun D DesaiUNKNOWN IWOAI Segmentation Challenge Writing Group
Jul 30, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Egor PanfilovVictor Casula

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