Brief Report: Cutaneous Melanoma Risk Among People With HIV in the United States and Canada

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Elizabeth L YanikRobert Dubrow

Abstract

Cutaneous melanoma incidence may be modestly elevated in people with HIV (PWH) vs. people without HIV. However, little is known about the relationship of immunosuppression, HIV replication, and antiretroviral therapy (ART) with melanoma risk. PWH of white race in the North American AIDS Cohort Collaboration on Research and Design were included. A standardized incidence ratio was calculated comparing risk with the white general population, standardizing by age, sex, and calendar period. Associations between melanoma incidence and current, lagged, and cumulative measures of CD4 count, HIV RNA level, and ART use were estimated with Cox regression, adjusting for established risk factors such as age and annual residential ultraviolet B (UVB) exposure. Eighty melanomas were diagnosed among 33,934 white PWH (incidence = 40.75 per 100,000 person-years). Incidence was not elevated compared with the general population [standardized incidence ratio = 1.15, 95% confidence interval (95% CI) = 0.91 to 1.43]. Higher melanoma incidence was associated with older age [adjusted hazard ratio (aHR) per decade increase = 1.50, 95% CI = 1.20 to 1.89] and higher UVB exposure (aHR for exposure ≥35 vs. <35 mW/m = 1.62, 95% CI = 0.99 to 2.65). Current, l...Continue Reading

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Citations

Aug 14, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael J SilverbergRomain S Neugebauer
Jul 13, 2019·F1000Research·Sarah J Coates, Kieron S Leslie
Feb 12, 2020·International Journal of Environmental Research and Public Health·Caradee Y WrightMary Norval
Feb 3, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yann RuffieuxEliane Rohner

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