Brief report: Does PTH increase with age, independent of 25-hydroxyvitamin D, phosphate, renal function, and ionized calcium?

The Journal of Clinical Endocrinology and Metabolism
Simon J CarrivickNarelle C Hadlow

Abstract

Circulating PTH concentrations increase with age. It is uncertain whether an age-related PTH increase occurs independent of changes in circulating 25-hydroxyvitamin D, phosphate, renal function, and ionized calcium. The purpose of this article was to analyze the relationship between PTH and age, controlling for 25-hydroxyvitamin D, phosphate, renal function, and ionized calcium. This was a retrospective, cross-sectional study analyzing the relationship between PTH and age in 2 independent datasets (laboratory 1, n = 17 275 and laboratory 2, n = 4878). We further analyzed subgroups after excluding participants with estimated glomerular filtration rate of <60 mL/min/1.73 m(2) or 25-hydroxyvitamin D of <50 nmol/L (for subgroups, n = 12 051 for laboratory 1 and 3473 for laboratory 2). After adjustment for sex, ionized calcium, 25-hydroxyvitamin D, phosphate, and estimated glomerular filtration rate, each 10-year increase in age was associated with a 5.0% increase in PTH (95% confidence interval [CI], 4.4%-5.6%; P < .001) in laboratory 1 and a 4.2% increase in laboratory 2 (95% CI, 3.0%-5.4%; P < .001). In the subgroups, each 10-year increase in age was associated with a 6.1% increase in PTH (95% CI, 5.5%-6.8%; P < .001) in laborato...Continue Reading

Citations

Feb 20, 2020·The Journal of Clinical Endocrinology and Metabolism·Marian SchiniRichard Eastell
Dec 22, 2017·Journal of the Endocrine Society·David BuchebnerKristina Åkesson
May 6, 2020·Archives of Osteoporosis·Dan Alexandru NiculescuCatalina Poiana
Jan 16, 2020·International Journal of Environmental Research and Public Health·Chin Yi ChanKok-Yong Chin
Dec 7, 2020·The Journal of Clinical Endocrinology and Metabolism·Malak El SabehGhada El-Hajj Fuleihan
Apr 7, 2021·Aging Clinical and Experimental Research·Jean-Marc Kaufman
May 18, 2021·Frontiers in Endocrinology·Dan Alexandru NiculescuCatalina Poiana
Sep 30, 2021·European Geriatric Medicine·Abayomi N OgunwaleNahid Rianon

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