Brief Report: Effects of Tenofovir and Amphotericin B Deoxycholate Coadministration on Kidney Function in Patients Treated for Cryptococcal Meningitis

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Reuben KiggunduASTRO-CM Team

Abstract

The effect of tenofovir and amphotericin coadministration on kidney function is poorly characterized. We measured creatinine during induction therapy and at 4 weeks after diagnosis in Ugandans undergoing cryptococcal meningitis therapy and classified as not receiving antiretroviral therapy (ART), receiving nontenofovir ART or receiving tenofovir-based ART. Longitudinal creatinine changes and grade 2-4 creatinine adverse events were evaluated across groups. Creatinine concentrations were similar across ART groups. At 4 weeks after diagnosis, creatinine was 0.25 mg/dL higher than at diagnosis, but similar across groups. Adverse event incidence was also similar across ART groups. Tenofovir and amphotericin coadministration did not increase the risk of kidney dysfunction.

References

Jun 1, 1991·The Journal of Clinical Investigation·B P SawayaJ Schnermann
Aug 26, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M H WhiteC B Miller
Dec 10, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J R WingardJ Lister
Mar 17, 2001·The Journal of Antimicrobial Chemotherapy·A D LuberB J Guglielmo
Jan 22, 2002·The Journal of Antimicrobial Chemotherapy·Gilbert Deray
Jun 24, 2008·The Journal of Antimicrobial Chemotherapy·Inmaculada Jiménez-NácherVincent Soriano
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Oct 20, 2009·Revista iberoamericana de micología·Rafael Laniado-Laborín, Maria Noemí Cabrales-Vargas
Mar 17, 2010·BMC Infectious Diseases·Joseph N JarvisThomas S Harrison
Jun 25, 2010·Tropical Medicine & International Health : TM & IH·Danielle B CohenFlorian Neuhann
Nov 16, 2010·Kidney International·Mark A Perazella
Mar 14, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Radha RajasinghamDavid R Boulware
May 10, 2012·JAMA : the Journal of the American Medical Association·Kunihiro MatsushitaUNKNOWN Chronic Kidney Disease Prognosis Consortium
Mar 8, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kara N DurskiDavid R Boulware
Apr 5, 2013·The New England Journal of Medicine·Jeremy N DayJeremy J Farrar
Nov 16, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Judith A Aberg Infectious Diseases Society of America
Dec 10, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph N JarvisThomas Harrison
Mar 4, 2014·The Journal of Infectious Diseases·Sophie JoseUNKNOWN UK Collaborative HIV Cohort Study Steering Committee
Jun 26, 2014·The New England Journal of Medicine·David R BoulwareUNKNOWN COAT Trial Team

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Citations

Dec 3, 2016·AIDS Research and Therapy·Sirawat Srichatrapimuk, Somnuek Sungkanuparph
Dec 11, 2019·Biomolecules·Maria E KrummenauerMarilene H Vainstein

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