Brief Report: Group 3 Innate Lymphoid Cells in Human Enthesis

Arthritis & Rheumatology
Richard J CuthbertDennis McGonagle

Abstract

Group 3 innate lymphoid cells (ILC3s) play a pivotal role in barrier tissues such as the gut and the skin, two important sites of disease in spondyloarthritis (SpA). This study was undertaken to investigate whether normal or injured human enthesis, a key target tissue in early SpA, harbors ILC3s in entheseal soft tissue and adjacent perientheseal bone. Interspinous ligament and spinous process bone from donors with no systemic inflammatory disease were collected, enzymatically digested, and immunophenotyped. The immunologic profile of entheseal cells was examined, and the transcriptional profile of sorted ILC3s was compared to that of ILC3s isolated from SpA synovial fluid (SF). To assess the ability of entheseal tissue to produce interleukin-17 (IL-17) and IL-22, entheseal digests were stimulated with IL-23 and IL-1β. Osteoarthritic and ruptured Achilles tendon tissue was examined histologically. The proportion of ILCs in human entheseal soft tissue was higher than that in peripheral blood (P = 0.008); entheseal soft tissue and perientheseal bone both had a higher proportion of NKp44+ ILC3s (P = 0.001 and P = 0.043, respectively). Studies of retinoic acid receptor-related orphan nuclear receptor γt (RORγt), STAT3, and IL-23 re...Continue Reading

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Citations

Nov 2, 2017·Calcified Tissue International·Margot Van MechelenRik Lories
Nov 22, 2017·Nature Reviews. Rheumatology·Georg SchettDennis McGonagle
May 31, 2018·Current Rheumatology Reports·Abdulla WatadDennis McGonagle
Jun 12, 2018·Current Opinion in Rheumatology·Charlie BridgewoodDennis McGonagle
Dec 24, 2018·Expert Review of Clinical Immunology·Sayam DubashHelena Marzo-Ortega
Apr 26, 2019·Annals of the Rheumatic Diseases·Charlie BridgewoodDennis G McGonagle
Oct 10, 2018·Annals of the Rheumatic Diseases·Stefan SiebertIain B McInnes
Sep 26, 2019·Nature Reviews. Rheumatology·Joachim SieperPierre Miossec
Nov 13, 2019·Current Rheumatology Reports·Susanne Juhl Pedersen, Walter P Maksymowych
Sep 19, 2019·Annals of the Rheumatic Diseases·Richard James CuthbertDennis G McGonagle
Feb 23, 2020·Nature Reviews. Rheumatology·Eric GraceyDirk Elewaut
Mar 12, 2020·Rheumatology·Elizabeth G Araujo, Georg Schett
Sep 12, 2019·Seminars in Immunopathology·Cuong Thach NguyenIannis E Adamopoulos
May 16, 2020·Current Opinion in Rheumatology·Adam Berlinberg, Kristine A Kuhn
Mar 5, 2020·Expert Opinion on Biological Therapy·Maurizio RossiniAnnamaria Iagnocco
Jul 15, 2020·Nature Reviews. Rheumatology·Eric GraceyDirk Elewaut
Jul 7, 2019·Annals of the Rheumatic Diseases·Dennis G McGonagleRobert Moots
Jul 29, 2020·Drugs·Gurjit S Kaeley, Jaspreet K Kaler
Mar 24, 2018·Seminars in Immunopathology·Tingting Xiong, Jan-Eric Turner
Jul 14, 2018·Zeitschrift für Rheumatologie·D SimonA J Hueber
Feb 14, 2020·Arthritis Research & Therapy·Weiting FangZhu Chen
Mar 10, 2020·The Journal of Clinical Investigation·Eric GraceyRobert D Inman
Jan 10, 2019·Journal of Immunology Research·Yumin WuWeifeng Shi
Sep 5, 2020·Paediatric Drugs·John M Bridges, Matthew L Stoll
May 22, 2018·Frontiers in Medicine·Aroldo RizzoFrancesco Ciccia
Mar 8, 2018·Therapeutic Advances in Chronic Disease·Sayam DubashHelena Marzo-Ortega
Sep 30, 2018·Nature Reviews. Rheumatology·Ellen M Gravallese, Georg Schett
Jun 15, 2019·Current Rheumatology Reports·Daniele MauroFrancesco Ciccia
Sep 10, 2020·International Journal of Molecular Sciences·Hiroyuki Tsukazaki, Takashi Kaito
Dec 7, 2018·Frontiers in Immunology·Abdulla WatadDennis McGonagle
Nov 9, 2018·Current Opinion in Rheumatology·Eric GraceyDirk Elewaut
Jan 23, 2021·Seminars in Immunopathology·Fatemeh NavidRobert A Colbert
Feb 12, 2021·Seminars in Immunopathology·Daniele MauroFrancesco Ciccia
Nov 3, 2020·Therapeutic Advances in Musculoskeletal Disease·Maria NovianiYing Ying Leung
Jan 26, 2021·Frontiers in Immunology·Nicolas Rosine, Corinne Miceli-Richard
Oct 15, 2020·Rheumatology·Kassem SharifDennis McGonagle

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