Brief Report on the Detection of the EGFR T790M Mutation in Exhaled Breath Condensate from Lung Cancer Patients

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Robert J SmythBryan T Hennessy

Abstract

The EGFR T790M somatic mutation is the most common mechanism of resistance to tyrosine kinase inhibitors in NSCLC. Patients with advanced disease are not always amenable to repeat biopsy for further molecular analysis. Developing noninvasive methods to detect T790M in cell-free DNA in the absence of tissue is being actively investigated. Unfortunately, the low sensitivity of plasma for detection of T790M has limited its clinical use. Exhaled breath condensate (EBC) is an easily collected sample that is known to harbor cell-free DNA, including lung cancer mutations. This report details the potential utility of exhaled breath condensate in the detection of the EGFR T790M mutation.

Citations

Jul 10, 2019·Journal of Breath Research·Annalisa CampanellaStefania Tommasi
Apr 11, 2019·Journal of Breath Research·Altug KocYasemin Basbinar
Sep 10, 2019·Technology in Cancer Research & Treatment·Jinliang ChenSumei Yao
Aug 26, 2021·Lung Cancer : Targets and Therapy·Nir PeledRaul Bitran
Jan 21, 2019·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ibiayi Dagogo-JackJochen K Lennerz

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