Brief Report: Progression of Atherosclerosis in HIV-Infected Individuals-Prospective Data From an Asian Cohort

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Grace LuiNelson Lee

Abstract

The magnitude and risk factors of progression of atherosclerosis in Asian HIV-infected individuals were unknown. This study aimed to evaluate: (1) the rate of progression of atherosclerosis in HIV-infected individuals, and (2) metabolic and inflammatory parameters that may predict atherosclerosis progression in HIV-infected individuals in an Asian cohort. A prospective, longitudinal study was performed among adults attending an HIV Metabolic clinic in Hong Kong. Carotid intima media thickness (cIMT) was measured at baseline and 24 months. Body composition, metabolic, and inflammatory biomarkers [including homeostasis model assessment of insulin resistance, LDL (low-density lipoprotein) cholesterol particle size, high-sensitive C reactive protein, adiponectin] associated with cIMT change were analyzed; their predictive performances were estimated using receiver operating characteristic analyses. Sixty-one HIV-infected individuals (mean ± SD age 49.8 ± 11.4 years, 89% men, 97% Chinese, diabetes 39%, hypertension 30%, and dyslipidemia 85%) were recruited. Annual rate of change of cIMT was +0.0075 (0.0000-0.0163) mm/yr, and 19% developed new plaque at 24 months. Two patients died during the study period, 1 because of sudden cardiac...Continue Reading

References

Jun 24, 1998·The Journal of Clinical Investigation·F R DeLeoW M Nauseef
Jan 7, 2005·The New England Journal of Medicine·Steven Grinspoon, Andrew Carr
Dec 24, 2005·QJM : Monthly Journal of the Association of Physicians·M Rizzo, K Berneis
Sep 9, 2006·Current Opinion in Lipidology·Nicola FerriAlberto Corsini
Apr 26, 2007·The Journal of Clinical Endocrinology and Metabolism·Virginia A TriantSteven K Grinspoon
Apr 27, 2007·The New England Journal of Medicine·UNKNOWN DAD Study GroupJens D Lundgren
Aug 23, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·N LeeJ J Y Sung
Jul 17, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rita B EffrosKevin P High
Oct 24, 2008·PLoS Medicine·Lewis H KullerUNKNOWN INSIGHT SMART Study Group
Sep 16, 2009·PloS One·Thomas L KellySteven B Heymsfield
Oct 13, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Grace LuiDavid S C Hui
Jun 15, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Marta GiraltFrancesc Villarroya
Dec 27, 2011·Stroke; a Journal of Cerebral Circulation·Hannah GardenerTatjana Rundek
Jan 3, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Aimin Xu, Paul M Vanhoutte
Jul 24, 2012·JAMA : the Journal of the American Medical Association·James H Stein, Priscilla Y Hsue
Mar 6, 2013·JAMA Internal Medicine·Matthew S FreibergAmy C Justice
May 17, 2014·JACC. Cardiovascular Imaging·James H SteinPriscilla Y Hsue
Jun 25, 2014·BMC Infectious Diseases·Paula FreitasJosé Luís Medina
Apr 12, 2015·Neurology·Jason J SicoUNKNOWN Veterans Aging Cohort Study
Apr 25, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Manisha DesaiDouglas K Owens

❮ Previous
Next ❯

Citations

May 3, 2019·Nature Communications·Luc BertrandMichal Toborek
Sep 19, 2019·AIDS Research and Human Retroviruses·Sarawut SiwamogsathamUNKNOWN HIV-NAT 227/HIV-NAT006 study team
Jul 10, 2021·Frontiers in Neurology·Antonio Spagnolo-Allende, Jose Gutierrez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.