Brief Report: The Amsterdam Symptom and Risk-Based Score Predicts for Acute HIV Infection in Men Who Have Sex With Men in San Diego

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Timothy C LinMartin Hoenigl

Abstract

Dijkstra et al recently described a risk- and symptom-based score moderately predictive for HIV seroconversion in the preceding 6-12 months in men who have sex with men (MSM) in Amsterdam. Our objective was to determine whether this "Amsterdam Score" could also predict for acute HIV infection (AHI) in MSM. This study is a case-control analysis of a prospectively enrolled cohort of MSM who voluntarily presented for HIV testing in San Diego. The study sample was composed of MSM who screened HIV antibody-negative and then either tested positive with AHI [HIV nucleic acid test (NAT)-positive] or tested HIV NAT-negative. The Amsterdam Score was calculated for each participant in the study sample. Score performance was assessed using receiver operating characteristic curves and their area under the curve (AUC). An optimal cutoff was determined using the Youden index. Seven hundred fifty-seven MSM (110 AHI and 647 HIV NAT-negative) were included in the analysis. AHI and HIV-negative cases were similar in age [median 32 years (interquartile range 26-42) vs 33 (27-45), respectively, P = 0.082]. The Amsterdam Score yielded a receiver operating characteristic curve with an AUC of 0.88 (95% confidence interval: 0.84 to 0.91). An optimal cu...Continue Reading

References

Jan 13, 2010·Archives of Internal Medicine·Pragna PatelUNKNOWN Centers for Disease Control and Prevention Acute HIV Infection Study Group
Mar 19, 2011·BMC Bioinformatics·Xavier RobinMarkus Müller
Apr 24, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Martin HoeniglSusan J Little
Feb 20, 2016·Emerging Infectious Diseases·Martin HoeniglSusan J Little
Jun 16, 2017·BMC Infectious Diseases·Maartje DijkstraMaarten F Schim van der Loeff
Jan 3, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Timothy C LinMartin Hoenigl

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Citations

Sep 10, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Maartje DijkstraMaarten F Schim van der Loeff
Oct 2, 2020·Journal of the International AIDS Society·Shaun PalmerEduard J Sanders

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