Brief Report: The Association of Chronic Pain and Long-Term Opioid Therapy With HIV Treatment Outcomes

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Jessica S MerlinRobert Gross

Abstract

Chronic pain occurs in up to 85% of persons living with HIV and is commonly treated with long-term opioid therapy (LTOT). We investigated the impact of chronic pain and LTOT on HIV outcomes. This was prospective cohort study conducted between July 2015 and July 2016 in 5 HIV primary care clinics. Chronic pain was defined as ≥moderate pain for ≥3 months on the Brief Chronic Pain Questionnaire. Chronic pain and LTOT were assessed at an index visit. Suboptimal retention, defined as at least one "no-show" to primary care, and virologic failure were measured over the subsequent year. Multivariable logistic regression models were built for each outcome adjusting for site. Among 2334 participants, 25% had chronic pain, 27% had suboptimal retention, 12% had virologic failure, and 19% were prescribed LTOT. Among individuals not on LTOT, chronic pain was associated with increased odds of suboptimal retention [adjusted odds ratio (aOR) 1.46, 95% confidence interval (CI): 1.10 to 1.93, P = 0.009] and virologic failure (aOR 1.97, 95% CI: 1.39 to 2.80, P < 0.001). Among individuals with chronic pain, there was no association between LTOT and retention, but LTOT was associated with lower rates of virologic failure (aOR 0.56, 95% CI: 0.33 to 0...Continue Reading

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Citations

Mar 14, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jessica S MerlinJane M Liebschutz
May 7, 2020·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Akila RajaRichard Saitz
Sep 13, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jessica S MerlinJane M Liebschutz
May 27, 2020·Molecular Pain·Dylan R AddisSaurabh Aggarwal
Apr 9, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·E Jennifer EdelmanBrandon D L Marshall
Feb 12, 2021·Journal of General Internal Medicine·Judith I TsuiKatharine A Bradley
Aug 13, 2020·Infectious Disease Clinics of North America·Jonathan A ColasantiJeffrey H Samet
Mar 30, 2021·Drug and Alcohol Dependence·Anisha P GangulyJudith I Tsui
Apr 24, 2021·Journal of the International Association of Providers of AIDS Care·Kinna ThakararJeffrey H Samet
May 8, 2021·Frontiers in Pharmacology·Huan-Jun LuZhi-Jun Zhang
Jun 8, 2021·Frontiers in Sociology·Ana VentuneacDavid C Perlman

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