Brief Report: Tubulointerstitial Damage in Lupus Nephritis: A Comparison of the Factors Associated With Tubulointerstitial Inflammation and Renal Scarring

Arthritis & Rheumatology
Alejandra Londoño JimenezAnna Broder

Abstract

To characterize and compare the factors associated with tubulointerstitial inflammation (TII) and tubulointerstitial scarring, defined as interstitial fibrosis and/or tubular atrophy (IF/TA), in patients with lupus nephritis (LN). We identified systemic lupus erythematosus patients who had renal biopsy results consistent with LN between 2005 and 2017. Clinical data were collected from medical records. Multivariable logistic regression models were fitted to assess factors associated with TII and with IF/TA (moderate-to-severe versus none/mild). Of 203 LN patients included, 41 (20%) had moderate-to-severe TII, 45 (22%) had moderate-to-severe IF/TA, and 21 (10%) had both. Multivariable logistic regression models showed that moderate-to-severe TII was associated with a shorter disease duration, African American race, proliferative LN, and an estimated glomerular filtration rate (eGFR) of <60 ml/minute/1.73 m2 at the time of biopsy. Hydroxychloroquine use was associated with significantly lower odds of moderate-to-severe TII (odds ratio 0.27 [95% confidence interval 0.10-0.70], P = 0.008). Similar to TII, factors associated with moderate-to-severe IF/TA included proliferative LN and eGFR <60 ml/minute/1.73 m2 at the time of biopsy. ...Continue Reading

References

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Citations

Sep 12, 2019·Immunology·Samanta C FunesAlexis M Kalergis
Dec 13, 2018·Nature Reviews. Rheumatology·Mariele GattoAndrea Doria
Jan 5, 2021·Current Opinion in Rheumatology·Anthony ChangKichul Ko
Feb 7, 2021·CEN Case Reports·Atsuki OhashiYoshitaka Maeda
Jan 6, 2021·Proceedings of the National Academy of Sciences of the United States of America·Sladjana Skopelja-GardnerKeith B Elkon
Jul 5, 2021·International Immunopharmacology·Ti ZhangZhen Cheng
Sep 18, 2021·Clinical Science·Erika I Boesen, Rahul M Kakalij
Dec 17, 2021·Lupus·Valentina PapaAnthony Chang

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