Brief vs. ultrabrief pulse ECT: focus on seizure quality

European Archives of Psychiatry and Clinical Neuroscience
Isabelle Brunner, Michael Grözinger

Abstract

The effect of electroconvulsive therapy (ECT) performed with ultrabrief pulse (UBP) stimulation has been found inferior to brief pulse (BP) ECT in various studies. We reinvestigated this issue using a new dosing strategy that is based on seizure quality instead of seizure threshold. There is a long history of studies associating ictal characteristics of ECT with the clinical outcome. Accordingly, we used the clinical status of the patient and the quality of the prior seizure to determine the dosage for the upcoming treatment-referred to as Clinical and Seizure Based Stimulation (CASBAS). This approach aims at continuously providing high-quality seizures to optimize the outcome. While this dosing strategy was applied in our department, the pulse width was changed for a period of time from BP to UBP. It was hypothesized that the procedure would: (1) maintain seizure quality and clinical outcome under both conditions and would; and (2) compensate the lesser clinical efficacy of UBP by an increase in stimulus intensity. 245 patients received an ECT course according to the dosing strategy described, 162 with brief pulse (BP) and 83 with ultrabrief pulse ECT (UBP). In a retrospective evaluation, seizure quality and clinical outcome (...Continue Reading

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Citations

Nov 28, 2019·Acta Psychiatrica Scandinavica·C H KellnerP Sienaert
Jul 3, 2021·Brain Sciences·Aida de Arriba-ArnauMikel Urretavizcaya
Aug 3, 2021·Nordic Journal of Psychiatry·Per Bergsholm, Tor Magne Bjølseth

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