Bright cyclic light rearing-mediated retinal protection against damaging light exposure in adrenalectomized mice

Experimental Eye Research
Masaki Tanito, Robert E Anderson

Abstract

Previous studies have shown that albino rats and mice raised in bright cyclic light are protected from light-induced retinal damage. We tested if the stress response mediated by the adrenal grand is involved in the initiation of this neuroprotective phenomenon. Balb/c mice that were adrenalectomized (Adrex) or sham operated at 28 days of age were kept under dim (5 lux) or bright (400 lux) cyclic light (12h on/off) for 2 weeks. Thereafter, their electroretinogram (ERG), outer nuclear layer (ONL) thickness and area, and plasma corticosterone levels were measured in animals with (dim+light and bright+light groups) and without (dim and bright groups) damaging light exposure (3000 lux for 24 h). In the dim+light group, a- and b-wave amplitudes and the ONL thicknesses and areas were significantly higher in the Adrex animals than the sham animals, indicating that adrenalectomy itself yielded retinal protection. In the Adrex animals, the ONL areas were significantly larger in the bright+light group than the dim+light group, indicating that bright cyclic light rearing yielded further retinal tolerance, even in the absence of the adrenal gland. In sham animals, the plasma corticosterone concentration did not change between the dim and th...Continue Reading

References

Jun 1, 1987·Experimental Eye Research·J S PennR E Anderson
Feb 19, 2003·Experimental Eye Research·Hirokazu SakaguchiJohn W Crabb
Oct 28, 2003·Investigative Ophthalmology & Visual Science·Feng LiRobert E Anderson
Apr 13, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Gérald SeematterLuc Tappy
Dec 22, 2004·Progress in Retinal and Eye Research·Andreas WenzelCharlotte E Remé
Jan 27, 2005·Investigative Ophthalmology & Visual Science·Hiroshi TomitaRobert E Anderson
Mar 5, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Masaki TanitoJunji Yodoi
Sep 28, 2005·Investigative Ophthalmology & Visual Science·Masaki TanitoRobert E Anderson

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Citations

Mar 11, 2008·Investigative Ophthalmology & Visual Science·Yogita KananAnne Kasus-Jacobi
Oct 22, 2008·The International Journal of Neuroscience·Ester María LópezJuan José López-Costa
May 14, 2021·Molecular and Cellular Biochemistry·Meenakshi MauryaTara Sankar Roy

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