Brimonidine Imprinted Hydrogels and Evaluation of Their Binding and Releasing Properties as New Ocular Drug Delivery Systems

Current Drug Delivery
Hediye Moghadam OmranipourSeyed Ahmad Mohajeri

Abstract

Molecular imprinting is a technique for preparation of specific polymeric receptors for recognition and selective binding of chemicals. Recently, molecularly imprinted soft contact lenses have been studied as novel ocular drug delivery systems. The aim of this work was to prepare, for the first time, a brimonidine (BRN) imprinted soft contact lens material and study of its binding and releasing properties in aqueous media. The hydrogels were prepared using hydroxyethyl methacrylate (HEMA) as a backbone monomer, methacrylic acid (MAA), methacrylamide (MAAM) and 4-vinylpyridine (4VP) as the functional monomers and ethylene glycol dimethacrylate (EGDMA) as a cross linker monomer. Different BRN: MAA molar ratios were also applied in feed composition of monomers to study the influence of molecular imprinting technique on their binding properties. The hydrogels were characterized by determination of their swelling and binding properties in water. Their loading and release properties were also studied using Korsmeyer-Peppas equation in normal saline (NaCl 0.9%) and artificial tear solution. Poly (HEMA-co-MAA) showed superior binding properties compared to other copolymers. Also molecular imprinting technique significantly increased th...Continue Reading

Citations

Sep 3, 2016·Pharmaceutical Development and Technology·Sajedeh KioomarsSeyed Ahmad Mohajeri
Oct 2, 2020·BioTechniques·Zahra El-SchichAnette Gjörloff Wingren
Feb 20, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Pinal ChaudhariShaila A Lewis
Aug 7, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Dan Chau Thuy NguyenLaurence Fitzhenry

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.