Brimonidine purite 0.1% versus brinzolamide 1% as adjunctive therapy to latanoprost in patients with glaucoma or ocular hypertension

Current Medical Research and Opinion
Douglas G Day, David A Hollander

Abstract

To evaluate the efficacy and tolerability of brimonidine purite 0.1% in comparison to brinzolamide 1% when used as adjunctive therapy to latanoprost 0.005% in patients with glaucoma or ocular hypertension. Randomized, single-center, investigator-masked, parallel-group clinical study. Patients with IOP >or= 18 mmHg while on once-daily latanoprost were randomized to adjunctive treatment with brimonidine purite TID (n = 20) or brinzolamide TID (n = 20) for 3 months. Intraocular pressure (IOP) was measured at 8 a.m., 10 a.m., and 4 p.m. at latanoprost-treated baseline and after 1 and 3 months of latanoprost and adjunctive therapy. A patient questionnaire was administered to evaluate the tolerability of eye drop instillation. Baseline mean diurnal IOP (+/- standard deviation, mmHg) on latanoprost was comparable between groups (brimonidine purite: 19.6 +/- 2.94; brinzolamide: 19.8 +/- 3.25; p = 0.846). Mean diurnal IOP at Month 3 was 16.3 +/- 2.63 mmHg with brimonidine purite and 17.8 +/- 2.19 mmHg with brinzolamide (p = 0.028). Adjunctive use of brimonidine purite provided greater IOP lowering than brinzolamide at 10 a.m. (p < 0.001) and 4 p.m. (p = 0.050) and equivalent IOP lowering to brinzolamide at 8 a.m. (p = 0.716). Blurred vi...Continue Reading

References

Jul 6, 2002·Archives of Ophthalmology·Eve J HigginbothamUNKNOWN Fixed Combination Investigative Group
Jan 14, 2003·Archives of Ophthalmology·M Cristina LeskeUNKNOWN Early Manifest Glaucoma Trial Group
Apr 29, 2005·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Hidetoshi TsukamotoHiromu K Mishima
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May 20, 2006·Current Medical Research and Opinion·David Covert, Alan L Robin
Mar 25, 2008·Therapeutics and Clinical Risk Management·Louis B Cantor

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Citations

Feb 22, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Quang H NguyenStephen M Goode
Mar 31, 2010·Current Medical Research and Opinion·Konstantin Gugleta
Feb 11, 2012·Current Medical Research and Opinion·Jin-Wei ChengGuo-Cai Lu
Jun 10, 2011·Current Medical Research and Opinion·James F T Li Yim, Donald M Montgomery
Apr 29, 2011·Experimental Eye Research·Stella Arthur, Louis B Cantor
Oct 1, 2014·Expert Opinion on Pharmacotherapy·Sky K ChewIvan Goldberg
Nov 9, 2018·Expert Opinion on Pharmacotherapy·Daniel J OhMark S Dikopf
Nov 30, 2016·Journal of Ophthalmology·Paul HarasymowyczRadmila Day

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