Brimonidine suppresses loss of retinal neurons and visual function in a murine model of optic neuritis

Neuroscience Letters
Xiaoli GuoTakayuki Harada

Abstract

Optic neuritis is inflammation of the optic nerve and is strongly associated with multiple sclerosis (MS), an inflammatory demyelinating syndrome of the central nervous system. It leads to retinal ganglion cell (RGC) death and can cause severe vision loss. Brimonidine (BMD) is a selective α2-adrenergic receptor agonist that is used clinically for the treatment of glaucoma. BMD lowers intraocular pressure, but recent evidence suggests that its therapeutic efficacy may also mediate through mechanisms independent of modulation of intraocular pressure. In this study, we examined the effects of topical administration of BMD on retinal degeneration during optic neuritis in experimental autoimmune encephalomyelitis (EAE), an animal model of MS. EAE was induced with MOG35-55 in C57BL/6J mice and BMD eyedrops were applied daily. In the EAE retina, the number of RGCs was significantly decreased and this effect was suppressed with BMD treatment. Consistent with histological analyses, the visual impairment observed in EAE mice was inhibited with BMD treatment, indicating the functional significance of the neuroprotective effect of BMD. Furthermore, BMD increased the expression level of basic fibroblast growth factor in the EAE retina, part...Continue Reading

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Citations

Jul 23, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Felix UlbrichJulia Biermann
Sep 15, 2017·Asia-Pacific Journal of Ophthalmology·Rathika KandasamyRobyn Guymer
Jun 6, 2018·International Ophthalmology Clinics·Rohini R Sigireddi, Benjamin J Frankfort
Sep 28, 2016·Scientific Reports·Xiaoli GuoTakayuki Harada
Mar 9, 2017·Oxidative Medicine and Cellular Longevity·Atsuko KimuraTakayuki Harada
Aug 28, 2018·Case Reports in Ophthalmological Medicine·Emilio CamposMarina Buzzi
Dec 4, 2019·Frontiers in Neuroscience·Maria Grazia RossinoGiovanni Casini
Dec 9, 2020·Cells·Yue RuanAdrian Gericke
Nov 24, 2020·Frontiers in Neurology·Yael Redler, Michael Levy
Dec 4, 2019·Archivos de la Sociedad Española de Oftalmología·P V Muñoz-RamónF J Muñoz-Negrete

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