Bripiodionen, a new inhibitor of human cytomegalovirus protease from Streptomyces sp. WC76599

Journal of Natural Products
Y Z ShuS P Manly

Abstract

Bripiodionen (1), a new natural product, was isolated from Streptomyces sp. WC76599 during the screening of microbial fermentation extracts for their ability to inhibit human cytomegalovirus protease. The structure of 1 was elucidated by spectroscopic methods. Compound 1 displayed inhibitory activity against human cytomegalovirus protease with an IC50 value of 30 microM.

Citations

Sep 11, 1999·Bioorganic & Medicinal Chemistry·W W OgilvieR Déziel
Nov 26, 1999·Antiviral Chemistry & Chemotherapy·A K Field
Feb 29, 2000·Antiviral Chemistry & Chemotherapy·L Waxman, P L Darke
Dec 2, 2006·Journal of Basic Microbiology·Julia SerkedjievaIskra Ivanova
Aug 14, 2021·Probiotics and Antimicrobial Proteins·Svetoslav Dimitrov TodorovIskra Vitanova Ivanova
Dec 12, 2002·Chemical Reviews·Liang Tong

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