brlA requires both zinc fingers to induce development.

Molecular and Cellular Biology
T H AdamsW E Timberlake

Abstract

Expression of the Aspergillus nidulans brlA gene induces a developmental pathway leading to the production of asexual spores. We have introduced mutations into brlA that are expected to disrupt either or both Cys2-His2 Zn(II) coordination sites postulated to exist in the BrlA polypeptide. The resultant brlA alleles fail to induce either the asexual reproductive pathway or the expression of development-specific genes. These data support the hypothesis that brlA encodes a nucleic acid-binding protein whose activity requires each of two zinc fingers.

References

Jun 1, 1988·Trends in Genetics : TIG·W E Timberlake, M A Marshall
Jan 15, 1988·Cell·R M Evans, S M Hollenberg
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T A Kunkel
Nov 1, 1972·Journal of General Microbiology·P T Oliver
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M M YeltonW E Timberlake

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Citations

Oct 29, 2013·Fungal Genetics and Biology : FG & B·Ji Young KangKwang Yeop Jahng
Jun 25, 2010·Fungal Genetics and Biology : FG & B·Ozgür BayramJulio Rodriguez-Romero
May 24, 2005·Applied Microbiology and Biotechnology·R te BiesebekeC A M J J van den Hondel
Jun 7, 2019·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Carmen Ruger-Herreros, Luis M Corrochano
Sep 5, 2002·Microbiology and Molecular Biology Reviews : MMBR·Ana M CalvoNancy P Keller
Aug 30, 2019·The Journal of Microbiology·Min-Ju KimHee-Soo Park
Oct 13, 2006·Eukaryotic Cell·Jae-Hyung Mah, Jae-Hyuk Yu
Jan 1, 1992·Molecular & General Genetics : MGG·A J ClutterbuckG Gupta
Mar 17, 1999·FEMS Microbiology Reviews·R Fischer
May 29, 2002·Biochimica Et Biophysica Acta·Kenneth C EhrlichPeter J Cotty
Apr 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·T H AdamsJ H Yu

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