Brønsted Acid Catalyzed Nitrile Synthesis from Aldehydes Using Oximes via Transoximation at Ambient Temperature

Organic Letters
Kengo HyodoKingo Uchida

Abstract

The Brønsted acid-catalyzed synthesis of nitriles is described via transoximation under mild conditions using an O-protected oxime as a more stable equivalent of explosive O-protected hydroxylamines. The nitrile was generated via an O-protected aldoxime produced from the aldehyde and an O-protected oxime through transoximation. The reaction could be performed on a 1 g scale.

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Citations

Oct 6, 2018·Organic & Biomolecular Chemistry·Karim MuratovDenis Chusov
Oct 23, 2018·Chemistry : a European Journal·Jitendra GurjarValery V Fokin
Aug 1, 2020·Organic & Biomolecular Chemistry·Bifu LiuYongbo Zhou
Sep 24, 2020·Chemical Communications : Chem Comm·Jun WuQian Shi

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