Brønsted Acid Enabled Nickel-Catalyzed Hydroalkenylation of Aldehydes with Styrene and its Derivatives

Angewandte Chemie
Xing-Wang HanQi-Lin Zhou

Abstract

A Brønsted acid enabled nickel-catalyzed hydroalkenylation of aldehydes and styrene derivatives has been developed. The Brønsted acid acts as a proton shuttle to transfer a proton from the alkene to the aldehyde, thereby leading to an economical and byproduct-free coupling. A series of synthetically useful allylic alcohols were obtained through one-step reactions from readily available styrene derivatives and aliphatic aldehydes in up to 88 % yield and with high linear selectivity.

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Citations

Nov 16, 2018·Angewandte Chemie·Xiaohua Liu, Xiaoming Feng
Mar 19, 2021·Journal of the American Chemical Society·Ben-Xian XiaoYing-Chun Chen
Dec 6, 2018·Journal of the American Chemical Society·Santiago CañellasMiquel À Pericàs
Sep 25, 2021·Organic Letters·Wei-Min FengQi-Lin Zhou
Oct 9, 2021·Nature Communications·Xiao-Biao YanHang Shi

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