Broad Genomic Sampling Reveals a Smut Pathogenic Ancestry of the Fungal Clade Ustilaginomycotina

Molecular Biology and Evolution
Teeratas KijpornyongpanM Catherine Aime

Abstract

Ustilaginomycotina is home to a broad array of fungi including important plant pathogens collectively called smut fungi. Smuts are biotrophs that produce characteristic perennating propagules called teliospores, one of which, Ustilago maydis, is a model genetic organism. Broad exploration of smut biology has been hampered by limited phylogenetic resolution of Ustilaginiomycotina as well as an overall lack of genomic data for members of this subphylum. In this study, we sequenced eight Ustilaginomycotina genomes from previously unrepresented lineages, deciphered ordinal-level phylogenetic relationships for the subphylum, and performed comparative analyses. Unlike other Basidiomycota subphyla, all sampled Ustilaginomycotina genomes are relatively small and compact. Ancestral state reconstruction analyses indicate that teliospore formation was present at the origin of the subphylum. Divergence time estimation dates the divergence of most extant smut fungi after that of grasses (Poaceae). However, we found limited conservation of well-characterized genes related to smut pathogenesis from U. maydis, indicating dissimilar pathogenic mechanisms exist across other smut lineages. The genomes of Malasseziomycetes are highly diverged from...Continue Reading

References

Mar 28, 2002·Nucleic Acids Research·A J EnrightC A Ouzounis
Sep 4, 2003·Genome Research·Li LiDavid S Roos
May 10, 2007·Mycologia·John W Taylor, Mary L Berbee
Nov 13, 2007·BMC Evolutionary Biology·Alexei J Drummond, Andrew Rambaut
Nov 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jun XuThomas L Dawson
Mar 20, 2008·Genome Research·Daniel R Zerbino, Ewan Birney
Mar 29, 2008·Briefings in Bioinformatics·Kazutaka Katoh, Hiroyuki Toh
Jun 10, 2008·Journal of Theoretical Biology·Tanja Gernhard
Oct 8, 2008·Nucleic Acids Research·Brandi L CantarelBernard Henrissat
Jun 9, 2010·Systematic Biology·Liang LiuScott V Edwards
Jun 19, 2010·Nature Reviews. Genetics·Bernard Dujon
Dec 15, 2010·Science·Jan SchirawskiRegine Kahmann
Dec 29, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sante GnerreDavid B Jaffe
Feb 22, 2011·Bioinformatics·Diego DarribaDavid Posada
May 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sébastien DuplessisFrancis Martin
May 27, 2011·American Journal of Botany·Meredith Blackwell
Feb 14, 2012·Fungal Genetics and Biology : FG & B·Mahajabeen PadamseeM Catherine Aime
Mar 1, 2012·Molecular Biology and Evolution·Alexei J DrummondAndrew Rambaut
May 9, 2012·Annual Review of Phytopathology·Pietro D Spanu
May 9, 2012·Nature Reviews. Microbiology·Sylvain Raffaele, Sophien Kamoun
Dec 19, 2012·Frontiers in Plant Science·Thomas S Nühse
Jan 19, 2013·Molecular Biology and Evolution·Kazutaka Katoh, Daron M Standley
Feb 9, 2013·Antonie van Leeuwenhoek·Tomas Allen Rush, M Catherine Aime
Mar 22, 2013·Biotechnology for Biofuels·Anthony LevasseurBernard Henrissat

❮ Previous
Next ❯

Citations

Apr 26, 2019·Biological Reviews of the Cambridge Philosophical Society·Miguel A Naranjo-Ortiz, Toni Gabaldón
Dec 10, 2019·FEMS Yeast Research·Masako TakashimaTakashi Sugita
Sep 11, 2019·Molecular Biology and Evolution·Brandon T Sinn, Craig F Barrett
Feb 20, 2019·Nature Ecology & Evolution·Adam J BewickRobert J Schmitz
Jul 25, 2019·Annual Review of Phytopathology·Weiliang ZuoGunther Doehlemann
Jan 25, 2019·Nature Microbiology·Erin K ZessSophien Kamoun
Jul 28, 2020·Microorganisms·Domingo Martínez-SotoClaudia Geraldine León-Ramírez
May 16, 2021·Fungal Genetics and Biology : FG & B·Teeratas Kijpornyongpan, M Catherine Aime
Mar 28, 2021·Molecular Biology and Evolution·Chun Shen LimChris M Brown

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.