Broad-range inhibition of enterovirus replication by OSW-1, a natural compound targeting OSBP

Antiviral Research
Lucian AlbulescuFrank J M van Kuppeveld

Abstract

Enteroviruses, e.g., polio-, coxsackie- and rhinoviruses, constitute a large genus within the Picornaviridae family of positive-strand RNA viruses and include many important pathogens linked to a variety of acute and chronic diseases. Despite their huge medical and economic impact, no approved antiviral therapy is yet available. Recently, the oxysterol-binding protein (OSBP) was implicated as a host factor for enterovirus replication. Here, we investigated the antiviral activity of the natural compound OSW-1, a ligand of OSBP that is under investigation as an anti-cancer drug. OSW-1 potently inhibited the replication of all enteroviruses tested, with IC50 values in the low nanomolar range, acted at the genome replication stage and was effective in all tested cell types of three different species. Importantly, OSBP overexpression rescued viral replication, demonstrating that the antiviral effect of OSW-1 is due to targeting OSBP. Together, we here report the anti-enterovirus activity of the natural anti-cancer compound OSW-1.

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Citations

Aug 13, 2015·Viruses·Lonneke van der LindenFrank J M van Kuppeveld
May 6, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Andreina BajAntonio Toniolo
Mar 30, 2016·Trends in Microbiology·Hilde M van der SchaarFrank J M van Kuppeveld
Oct 30, 2016·Biochimie·Joachim Moser von Filseck, Guillaume Drin
Mar 28, 2017·Organic & Biomolecular Chemistry·M HiraizumiK Sakurai
Apr 8, 2018·Nature Reviews. Microbiology·Jim BaggenFrank J M van Kuppeveld
Jun 28, 2018·Journal of Lipid Research·An NguyenMichael J O Wakelam
Oct 20, 2018·Nature Reviews. Molecular Cell Biology·Louise H WongTim P Levine
Dec 27, 2018·Cellular Microbiology·Alberto Fernández-OlivaCristina Risco
Feb 24, 2017·Journal of Virology·Anabel GuedánRoberto Solari
Sep 24, 2016·Clinical Science·Ugo Soffientini, Annette Graham
Mar 15, 2018·Cellular and Molecular Life Sciences : CMLS·Antonietta Pietrangelo, Neale D Ridgway
Sep 26, 2020·Frontiers in Microbiology·Xinhong LiXiaoyue Chen
Jun 20, 2020·Expert Opinion on Therapeutic Targets·Mira LaajalaVarpu Marjomäki
May 26, 2020·Cell Biology International·Shiva ShahmohamadnejadSeyed Mohammad Nabavi
Aug 15, 2020·Frontiers in Cell and Developmental Biology·Nicolas-Frédéric LippGuillaume Drin
Jan 28, 2021·Viruses·Christine E Peters, Jan E Carette
Apr 4, 2021·Viruses·Terry Jackson, Graham J Belsham
Jul 5, 2019·Antiviral Research·Brett L RobertsAnthony W G Burgett
Jun 3, 2021·Viruses·Maria Musarra-PizzoMaria Teresa Sciortino
Jul 13, 2021·Frontiers in Microbiology·Kiran AvulaGulam H Syed
Jul 29, 2021·Open Biology·Aušra DomanskaSarah J Butcher

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