Broad Range of Hepatitis B Virus (HBV) Patterns, Dual Circulation of Quasi-Subgenotype A3 and HBV/E and Heterogeneous HBV Mutations in HIV-Positive Patients in Gabon

PloS One
Berthold Bivigou-MboumbaFrançois Rouet

Abstract

Integrated data on hepatitis B virus (HBV) patterns, HBV genotypes and mutations are lacking in human immunodeficiency virus type 1 (HIV-1) co-infected patients from Africa. This survey was conducted in 2010-2013 among 762 HIV-1-positive adults from Gabon who were predominantly treated with 3TC-based antiretroviral treatment. HBV patterns were identified using immunoassays detecting total antibody to hepatitis B core antigen (HBcAb), hepatitis B surface antigen (HBsAg), IgM HBcAb, hepatitis B e antigen (HBeAg), antibody to HBsAg (HBsAb) and an in-house real-time PCR test for HBV DNA quantification. Occult hepatitis B (OBI) was defined by the presence of isolated anti-HBc with detectable serum HBV DNA. HBV genotypes and HBV mutations were analyzed by PCR-direct sequencing method. Seventy-one (9.3%) patients tested positive for HBsAg, including one with acute hepatitis B (0.1%; 95% CI, 0.0%-0.2%), nine with HBeAg-positive chronic hepatitis B (CHB) (1.2%; 95% CI, 0.6%-2.2%), 16 with HBeAg-negative CHB (2.1%; 95% CI, 1.2%-3.3%) and 45 inactive HBV carriers (5.9%; 95% CI, 4.4%-7.8%). Sixty-one (8.0%; 95% CI, 6.2%-10.1%) patients showed OBI. Treated patients showed similar HBV DNA levels to those obtained in untreated patients, regar...Continue Reading

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Citations

Jan 30, 2018·Transactions of the Royal Society of Tropical Medicine and Hygiene·Bright NsokoloPaul Kelly
Aug 7, 2018·PLoS Neglected Tropical Diseases·Jolynne MokayaPhilippa C Matthews
Aug 25, 2018·Journal of Viral Hepatitis·Soraya GrocPierre Becquart
Feb 17, 2017·Journal of Clinical Microbiology·Sheila Makiala-MandandaPierre Becquart
Jan 10, 2018·PloS One·Berthold Bivigou-MboumbaSandrine François-Souquière
Apr 14, 2018·PloS One·Jean Marie Eko MbaBolni Marius Nagalo
Dec 7, 2018·Wellcome Open Research·Jolynne MokayaPhilippa C Matthews

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Datasets Mentioned

BETA
KM983561
KM983588
KT724763
KT724776

Methods Mentioned

BETA
genotyping
ELISA
PCR

Software Mentioned

ClustalW
Mutation Reporter Tool
FigTree
MrBayes
TRACER

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