Broad receptor engagement of an emerging global coronavirus may potentiate its diverse cross-species transmissibility

Proceedings of the National Academy of Sciences of the United States of America
Wentao LiBerend-Jan Bosch

Abstract

Porcine deltacoronavirus (PDCoV), identified in 2012, is a common enteropathogen of swine with worldwide distribution. The source and evolutionary history of this virus is, however, unknown. PDCoV belongs to the Deltacoronavirus genus that comprises predominantly avian CoV. Phylogenetic analysis suggests that PDCoV originated relatively recently from a host-switching event between birds and mammals. Insight into receptor engagement by PDCoV may shed light into such an exceptional phenomenon. Here we report that PDCoV employs host aminopeptidase N (APN) as an entry receptor and interacts with APN via domain B of its spike (S) protein. Infection of porcine cells with PDCoV was drastically reduced by APN knockout and rescued after reconstitution of APN expression. In addition, we observed that PDCoV efficiently infects cells of unusual broad species range, including human and chicken. Accordingly, PDCoV S was found to target the phylogenetically conserved catalytic domain of APN. Moreover, transient expression of porcine, feline, human, and chicken APN renders cells susceptible to PDCoV infection. Binding of PDCoV to an interspecies conserved site on APN may facilitate direct transmission of PDCoV to nonreservoir species, includin...Continue Reading

References

Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R K WilliamsK V Holmes
Jan 1, 1982·Physiological Reviews·A J Kenny, S Maroux
Oct 1, 1996·The Journal of General Virology·A F KolbS G Siddell
Apr 16, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·V H van der VeldenM A Versnel
Mar 26, 2005·The EMBO Journal·Wenhui LiMichael Farzan
May 18, 2005·Proceedings of the National Academy of Sciences of the United States of America·Heike HofmannStefan Pöhlmann
Apr 11, 2006·The Journal of General Virology·Christine WinterGeorg Herrler
Feb 3, 2007·Journal of Virology·D VijaykrishnaY Guan
Jul 8, 2008·Trends in Molecular Medicine·Paola Mina-Osorio
Nov 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kailang WuFang Li
Dec 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Andrew KitchenEdward C Holmes
May 27, 2011·Journal of Virology·Kazuya ShiratoFumihiro Taguchi
Sep 12, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Mark WoolhouseMargo Chase-Topping
Oct 17, 2012·Proceedings of the National Academy of Sciences of the United States of America·Lang ChenFang Li
Nov 5, 2013·Antiviral Research·Jan Felix DrexlerChristian Drosten
Apr 12, 2014·Genome Announcements·Ganwu LiJianqiang Zhang
Jun 26, 2014·Emerging Infectious Diseases·Leyi WangYan Zhang
Aug 26, 2014·Genome Announcements·Abdelbaset I YagubiAntonet M Svircev
Dec 3, 2014·Virus Research·Jean Kaoru Millet, Gary R Whittaker
Mar 27, 2015·Emerging Infectious Diseases·Kwonil JungLinda J Saif
Apr 22, 2015·PloS One·Damaris Bausch-FluckBernd Wollscheid
Sep 18, 2015·Journal of Virology·Victor Max CormanJan Felix Drexler
Nov 20, 2015·Emerging Infectious Diseases·Nan DongShaobo Xiao
Mar 5, 2016·Nature·Robert N KirchdoerferAndrew B Ward

❮ Previous
Next ❯

Citations

Jan 10, 2019·Animal Science Journal = Nihon Chikusan Gakkaihō·Jianwen ChenYunhai Zhang
Jan 23, 2020·International Journal of Molecular Sciences·Jiayu FuXiaobo Huang
Feb 25, 2020·Emerging Microbes & Infections·Yue-Lin YangYan-Dong Tang
Apr 3, 2020·Nature·Roman WölfelClemens Wendtner
Jun 9, 2020·Clinical and Translational Medicine·Liyang LiXiangdong Wang
Jun 23, 2020·The Journal of General Virology·Natacha S OgandoEric J Snijder
May 15, 2020·Molecular Biology and Evolution·Wan-Ting HeShuo Su
Jul 17, 2020·FEMS Microbiology Reviews·Michelle Wille, Edward C Holmes
Aug 23, 2020·Nanomaterials·Sangiliyandi GurunathanHyuk Song
Sep 3, 2020·Pathogens and Global Health·Manoj KhokharPuneet Setia
Aug 18, 2020·Transboundary and Emerging Diseases·Guangzhi ZhangShangjin Cui
Mar 12, 2019·Frontiers in Veterinary Science·Surapong KoonpaewAnan Jongkaewwattana
Aug 16, 2019·Viruses·Shan ZhaoHerman Egberink
Jan 22, 2020·Emerging Infectious Diseases·Patricia A BoleyScott P Kenney
Sep 28, 2020·Molecular Neurobiology·Hamid Soltani ZangbarTahereh Ghadiri
Jun 27, 2019·Viruses·Qingqing LiangHui Hu
Aug 7, 2019·Current Opinion in Organ Transplantation·Jay A Fishman
Mar 29, 2020·JAMA Cardiology·Mohammad MadjidOrly Vardeny
Oct 14, 2018·Transgenic Research·Kristin M WhitworthRandall S Prather
Apr 25, 2020·International Journal of Molecular Sciences·Ayumu AsaiHideshi Ishii
Oct 14, 2020·Proceedings of the National Academy of Sciences of the United States of America·Caitlin E EdwardsRalph S Baric
Dec 2, 2020·Emerging Topics in Life Sciences·Ny Anjara Fifi RavelomanantsoaCara E Brook
Oct 30, 2020·FEMS Microbiology Reviews·Jean K MilletGary R Whittaker
Dec 3, 2020·Drug Metabolism Reviews·Philip G Board, M W Anders
Dec 31, 2020·Vaccines·Hans Van der WekenBert Devriendt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.