PMID: 11607550Jun 20, 1995Paper

Broad resistance to plant viruses in transgenic plants conferred by antisense inhibition of a host gene essential in S-adenosylmethionine-dependent transmethylation reactions

Proceedings of the National Academy of Sciences of the United States of America
C MasutaM Noma

Abstract

S-Adenosylhomocysteine hydrolase (SAHH) is a key enzyme in transmethylation reactions that use S-adenosylmethionine as the methyl donor. Because of the importance of SAHH in a number of S-adenosylmethionine-dependent transmethylation reactions, particularly the 5' capping of mRNA during viral replication, SAHH has been considered as a target of potential antiviral agents against animal viruses. To test the possibility of engineering a broad type of resistance to plant viruses, we expressed the antisense RNA for tobacco SAHH in transgenic tobacco plants. As expected, transgenic plants constitutively expressing an anti-sense SAHH gene showed resistance to infection by various plant viruses. Among those plants, about half exhibited some level of morphological change (typically stunting). Analysis of the physiological change in those plants showed that they contained excess levels of cytokinin. Because cytokinin has been found to induce acquired resistance, there is also a strong possibility that the observed resistance was induced by cytokinin.

References

Jan 1, 1976·Archives of Biochemistry and Biophysics·J E Poulton, V S Butt
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J M AndersonM Zaitlin
May 1, 1991·Journal of Medicinal Chemistry·M S Wolfe, R T Borchardt
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D B GolemboskiM Zaitlin
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R J HohmanM Veron
Jun 1, 1983·Journal of Medicinal Chemistry·H IwamuraS Matsubara
Oct 1, 1958·Virology·J L TROUTMAN, R W FULTON
Dec 1, 1990·Plant Physiology·J S TaylorR P Pharis

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Citations

Jan 1, 2002·The Arabidopsis Book·Barbara A Moffatt, Hiroshi Ashihara
Dec 18, 2004·Plant Molecular Biology·William G Heim, John G Jelesko
May 24, 2013·Molecular Plant-microbe Interactions : MPMI·M Carmen CañizaresEnrique Moriones
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·S RavanelR Douce
Apr 8, 2011·Trends in Plant Science·Jaemyung ChoiIldoo Hwang
Mar 24, 2010·Journal of Virological Methods·Pu YanPeng Zhou
Mar 5, 2016·Molecular Genetics and Genomics : MGG·Haiyan ZhangYanying Qu
Mar 11, 2015·Plant Biotechnology Journal·Douglas E Pyott, Attila Molnar
Sep 4, 2007·Plant Biotechnology Journal·Atsushi NagamatsuAkira Kanazawa
Dec 24, 2010·The Plant Journal : for Cell and Molecular Biology·Akira KanazawaChikara Masuta
Sep 16, 2014·Molecular Plant Pathology·Mazen Alazem, Na-Sheng Lin
Jun 26, 2015·Journal of Experimental Botany·Muhammad NaseemThomas Dandekar
Apr 23, 2015·Plant Science : an International Journal of Experimental Plant Biology·Petra SpoustováHelena Synková
Sep 29, 2012·Biochimica Et Biophysica Acta·Oksana TehlivetsWalter Keller
Feb 3, 2007·Journal of Experimental Botany·L A R PereiraB A Moffatt
Nov 28, 2018·The Plant Journal : for Cell and Molecular Biology·Guoping WangWenyi Wang
Mar 30, 2017·Archives of Virology·S CheewachaiwitO Chatchawankanphanich
Jul 7, 2009·Journal of Proteome Research·Cristina-Maria ValcuKatja Schlink
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Pedro VizánSergi Aranda
Apr 9, 2019·Current Opinion in Plant Biology·Kristiina Mäkinen, Swarnalok De

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