Abstract
The in vitro inhibitory activities of four currently used antimycotic agents (clotrimazole, econazole, miconazole and cyclopirox-olamine) against 304 fungal isolates comprising 51 species from 14 genera of moulds and yeasts, using a serial dilution procedure, were studied. Clotrimazole and econazole were found to have a grossly similar broad-spectrum antifungal activity, inhibiting all the tested yeasts and moulds at a concentration ranging from 0.1-4 micrograms/ml. At this range miconazole inhibited 90 per cent of the strains and cyclopirox-olamine inhibited 57 per cent only and thus they were less effective. Econazole 1 per cent solution was very effective in vivo in the treatment of otomycosis within 1-3 weeks. The drug was well tolerated, with no side-effects. Owing to the high broad-spectrum antifungal activity of clotrimazole and econazole, they should be the treatment of choice in otomycosis and can be used safely as otic drops.
References
Nov 1, 1978·The Laryngoscope·T L LawrenceW H Saunders
Mar 1, 1974·The Journal of Laryngology and Otology·J Schönebeck, J E Zakrisson
Sep 1, 1967·The Journal of Laryngology and Otology·V P SoodL N Mohapatra
Feb 1, 1983·The Journal of Antimicrobial Chemotherapy·H YamaguchiM Plempel
Jul 1, 1980·The American Journal of Tropical Medicine and Hygiene·K M ThanM Min
Nov 1, 1980·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·L Lopez, R P Evens
Mar 1, 1982·The Journal of Laryngology and Otology·A MaherD S Hendawy
Mar 1, 1982·The Journal of Laryngology and Otology·A BassiounyD S Hendawy
Feb 1, 1961·The Journal of Laryngology and Otology·A E GREGSON, C J LA TOUCHE
Nov 29, 1964·Biochimica Et Biophysica Acta·J H ANGLIN, M A EVERETT
Citations
Mar 31, 2012·Medical Mycology·Vit HubkaMiroslav Kolarik
Jan 5, 2002·Mycoses·N Mgbor, H C Gugnani
Apr 19, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Shadman NematiAzimeh Delkhosh Nasrollah Abadi
Apr 14, 2000·The Laryngoscope·L W Tom
Jan 11, 2016·Veterinary Dermatology·Elizabeth C GoodaleStephen D White
Feb 19, 2008·International Journal of Pediatric Otorhinolaryngology·Raymundo Munguia, Sam J Daniel
May 25, 2010·Veterinary Dermatology·Kimberly Coyner
Apr 23, 2010·Veterinary Dermatology·Giovanni Ghibaudo, Andrea Peano
Nov 26, 2015·The Laryngoscope·Khrystyna HerasymShaun Kilty
Jan 17, 2014·Medical Mycology Case Reports·Sourour NejiAyadi Ali
Jan 27, 2015·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Nagendran Navaneethan, Raj Prakash Dharmapuri YaadhavaKrishnan
Jan 1, 1989·The Journal of Laryngology and Otology·K O PauloseR K Sharma
Jan 1, 1996·Mycopathologia·J ChanderA Handa
May 7, 2003·The Annals of Otology, Rhinology, and Laryngology·Bibhu PradhanRamchaya Man Amatya
Dec 14, 2007·Mycoses·James FasunlaPaul Onakoya
Feb 1, 2002·Mycoses·P Kurnatowski, A Filipiak
May 1, 1989·Mycoses·H C GugnaniA N Njoku-Obi
Mar 21, 2012·Ear, Nose, & Throat Journal·Borlingegowda ViswanathaMaliyappanahalli Siddappa Vijayashree
Sep 20, 2012·The Laryngoscope·Ronen PerezJean-Yves Sichel
May 26, 2021·The Cochrane Database of Systematic Reviews·Ambrose LeeShakeel R Saeed
Jun 3, 2021·Pathogens·Yassine MeradMalika Belkacemi