Broad-spectrum antimicrobial polycarbonate hydrogels with fast degradability

Biomacromolecules
Ana PascualHaritz Sardon

Abstract

In this study, a new family of broad-spectrum antimicrobial polycarbonate hydrogels has been successfully synthesized and characterized. Tertiary amine-containing eight-membered monofunctional and difunctional cyclic carbonates were synthesized, and chemically cross-linked polycarbonate hydrogels were obtained by copolymerizing these monomers with a poly(ethylene glycol)-based bifunctional initiator via organocatalyzed ring-opening polymerization using 1,8-diazabicyclo[5.4.0]undec-7-ene catalyst. The gels were quaternized using methyl iodide to confer antimicrobial properties. Stable hydrogels were obtained only when the bifunctional monomer concentration was equal to or higher than 12 mol %. In vitro antimicrobial studies revealed that all quaternized hydrogels exhibited broad-spectrum antimicrobial activity against Staphylococcus aureus (Gram-positive), Escherichia coli (Gram-negative), Pseudomonas aeruginosa (Gram-negative), and Candida albicans (fungus), while the antimicrobial activity of the nonquaternized hydrogels was negligible. Moreover, the gels showed fast degradation at room temperature (4-6 days), which makes them ideal candidates for wound healing and implantable biomaterials.

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Citations

Sep 7, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Marta RibeiroHaritz Sardon
Jan 6, 2017·Molecular Pharmaceutics·Xiaoliang QiWei Dong
Mar 7, 2017·International Wound Journal·Calver PangPatrizia Ferretti
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Dec 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pierre-Luc DurandHenri Cramail
May 16, 2017·Advanced Healthcare Materials·Jeremy P K TanJames L Hedrick
Apr 10, 2019·Polymers·Alexander Y YuenHaritz Sardon
May 14, 2018·Polymer Chemistry·Shrinivas VenkataramanYi Yan Yang
Nov 28, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yanliang DongAnjie Dong
Dec 17, 2020·Biomedical Materials·Günnur OnakOzan Karaman
Jun 12, 2017·ACS Biomaterials Science & Engineering·Zhiqiang ZhengFeng Yan
Jan 10, 2020·ACS Applied Materials & Interfaces·Christian KrummJoerg C Tiller
Jan 8, 2018·ACS Biomaterials Science & Engineering·Peng LiuEn-Tang Kang

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