Broad-spectrum drugs against viral agents

International Journal of Molecular Sciences
Mary E Christopher, Jonathan P Wong

Abstract

Development of antivirals has focused primarily on vaccines and on treatments for specific viral agents. Although effective, these approaches may be limited in situations where the etiologic agent is unknown or when the target virus has undergone mutation, recombination or reassortment. Augmentation of the innate immune response may be an effective alternative for disease amelioration. Nonspecific, broad-spectrum immune responses can be induced by double-stranded (ds)RNAs such as poly (ICLC), or oligonucleotides (ODNs) containing unmethylated deocycytidyl-deoxyguanosinyl (CpG) motifs. These may offer protection against various bacterial and viral pathogens regardless of their genetic makeup, zoonotic origin or drug resistance.

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Methods Mentioned

BETA
transfection
PCR

Related Concepts

Antiviral Agents
Drug Resistance
Oligonucleotides
Poly A
Recombination, Genetic
RNA, Double-Stranded
Vaccines
Virus
Zoonoses
Oligonucleotides, Antisense

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