Broad-Spectrum Host-Based Antivirals Targeting the Interferon and Lipogenesis Pathways as Potential Treatment Options for the Pandemic Coronavirus Disease 2019 (COVID-19)

Viruses
Shuofeng YuanJasper Fuk-Woo Chan

Abstract

The ongoing Coronavirus Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) signals an urgent need for an expansion in treatment options. In this study, we investigated the anti-SARS-CoV-2 activities of 22 antiviral agents with known broad-spectrum antiviral activities against coronaviruses and/or other viruses. They were first evaluated in our primary screening in VeroE6 cells and then the most potent anti-SARS-CoV-2 antiviral agents were further evaluated using viral antigen expression, viral load reduction, and plaque reduction assays. In addition to remdesivir, lopinavir, and chloroquine, our primary screening additionally identified types I and II recombinant interferons, 25-hydroxycholesterol, and AM580 as the most potent anti-SARS-CoV-2 agents among the 22 antiviral agents. Betaferon (interferon-β1b) exhibited the most potent anti-SARS-CoV-2 activity in viral antigen expression, viral load reduction, and plaque reduction assays among the recombinant interferons. The lipogenesis modulators 25-hydroxycholesterol and AM580 exhibited EC50 at low micromolar levels and selectivity indices of >10.0. Combinational use of these host-based antiviral agents with virus-based antivi...Continue Reading

References

Oct 5, 2001·Clinical Microbiology Reviews·C E Samuel
Mar 19, 2002·Antimicrobial Agents and Chemotherapy·Y FurutaK Shiraki
Aug 2, 2003·Lancet·J CinatlH W Doerr
Nov 1, 2003·The Lancet Infectious Diseases·Andrea SavarinoRoberto Cauda
Feb 26, 2004·Nature Medicine·Bart L HaagmansAlbert D M E Osterhaus
Jun 18, 2004·Emerging Infectious Diseases·Emily L C TanLawrence W Stanton
Aug 7, 2004·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Bojian ZhengHsiang-Fu Kung
Sep 8, 2004·Biochemical and Biophysical Research Communications·Els KeyaertsMarc Van Ranst
Apr 13, 2011·The Journal of Antimicrobial Chemotherapy·Sibel AsciogluK Arnold Chan
Oct 8, 2013·The Journal of Infection·Jasper F W ChanKwok-Yung Yuen
Oct 22, 2013·Cell Host & Microbe·John W Schoggins, Glenn Randall
Jun 18, 2014·American Journal of Respiratory and Critical Care Medicine·Ratko DjukanovićUNKNOWN INTERCIA Study Group
Jul 6, 2014·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth S GoldAlan Aderem
Aug 27, 2014·Antimicrobial Agents and Chemotherapy·Justin G JulanderYarlagadda S Babu
Feb 13, 2016·Nature Reviews. Drug Discovery·Alimuddin ZumlaKwok-Yung Yuen
Apr 21, 2016·Journal of Infection and Public Health·Raymond TaylorWilliam P Sheridan
Dec 3, 2016·Proceedings of the National Academy of Sciences of the United States of America·Hanna RetallackJoseph L DeRisi
Mar 7, 2017·Scientific Reports·Michael K LoChristina F Spiropoulou
Jul 1, 2017·Science Translational Medicine·Timothy P SheahanRalph S Baric
Jan 12, 2019·Nature Communications·Shuofeng YuanKwok-Yung Yuen
Dec 19, 2019·Journal of Chemical Information and Modeling·Felipe R S SantosJaqueline M S Ferreira

❮ Previous
Next ❯

Citations

Jun 26, 2020·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Sandra Pellegrini, Gilles Uzé
Oct 2, 2020·Current Opinion in HIV and AIDS·Ivan F N Hung
Feb 16, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Ailar NakhlbandHosein Azizi
Mar 6, 2021·Emerging Microbes & Infections·Kelvin Kai-Wang ToKwok-Yung Yuen
Feb 28, 2021·European Journal of Medicinal Chemistry·Juan WangYan Xu
Mar 1, 2021·Clinical Pharmacology and Therapeutics·Silke GastineJoseph F Standing
Apr 24, 2021·ELife·David W SandersClifford P Brangwynne
Nov 6, 2021·Frontiers in Immunology·Collins N KhwatengeYongming Sang

❮ Previous
Next ❯

Datasets Mentioned

BETA
MT230904

Methods Mentioned

BETA
Assay

Software Mentioned

Excel
SigmaPlot
SPSS
Immukin

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Related Papers

Frontiers in Plant Science
Tatiana MatveevaSofia Sokornova
The New England Journal of Medicine
Satoshi KutsunaAkihiro Matsunaga
© 2022 Meta ULC. All rights reserved