Broadband absorption and reduced scattering spectra of in-vivo skin can be noninvasively determined using δ-P1 approximation based spectral analysis

Biomedical Optics Express
Cheng-Hung HungSheng-Hao Tseng

Abstract

Previously, we revealed that a linear gradient line source illumination (LGLSI) geometry could work with advanced diffusion models to recover the sample optical properties at wavelengths where sample absorption and reduced scattering were comparable. In this study, we employed the LGLSI geometry with a broadband light source and utilized the spectral analysis to determine the broadband absorption and scattering spectra of turbid samples in the wavelength range from 650 to 1350 nm. The performance of the LGLSI δ-P1 diffusion model based spectral analysis was evaluated using liquid phantoms, and it was found that the sample optical properties could be properly recovered even at wavelengths above 1000 nm where μs' to μa ratios were in the range between 1 to 20. Finally, we will demonstrate the use of our system for recovering the 650 to 1350 nm absorption and scattering spectra of in-vivo human skin. We expect this system can be applied to study deep vessel dilation induced hemoglobin concentration variation and determine the water and lipid concentrations of in-vivo skin in clinical settings in the future.

References

Oct 1, 1994·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·R C HaskellB J Tromberg
Jan 1, 1997·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·A Kienle, M S Patterson
Apr 26, 2005·Journal of Biomedical Optics·Enrico GrattonAndrew Webb
Mar 5, 2008·Journal of Biomedical Optics·Sheng-Hao TsengAnthony J Durkin
May 9, 2009·IEEE Transactions on Bio-medical Engineering·Janelle E BenderNirmala Ramanujam
Aug 19, 2009·Optics Express·Sheng-Hao TsengNikiforos Kollias
Sep 10, 2009·Journal of Biophotonics·Lise Lyngsnes RandebergLars Othar Svaasand
Jan 12, 2010·Applied Optics·Narasimhan RajaramJames W Tunnell
Jul 10, 2010·Journal of Biomedical Optics·Rami NachabéHenricus J C M Sterenborg
Jan 25, 2011·Biomedical Optics Express·Steven L JacquesNiloy Choudhury
Aug 15, 2014·Journal of Biomedical Optics·Robert H WilsonAnthony J Durkin

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Citations

Sep 5, 2020·Biomedical Engineering and Computational Biology·Martha Z Vardaki, Nikolaos Kourkoumelis
Sep 26, 2015·Journal of Biomedical Optics·Ilona KuzminaLauma Valeine

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