Broadband Electrophysiological Dynamics Contribute to Global Resting-State fMRI Signal

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Haiguang Wen, Zhongming Liu

Abstract

Spontaneous activity observed with resting-state fMRI is used widely to uncover the brain's intrinsic functional networks in health and disease. Although many networks appear modular and specific, global and nonspecific fMRI fluctuations also exist and both pose a challenge and present an opportunity for characterizing and understanding brain networks. Here, we used a multimodal approach to investigate the neural correlates to the global fMRI signal in the resting state. Like fMRI, resting-state power fluctuations of broadband and arrhythmic, or scale-free, macaque electrocorticography and human magnetoencephalography activity were correlated globally. The power fluctuations of scale-free human electroencephalography (EEG) were coupled with the global component of simultaneously acquired resting-state fMRI, with the global hemodynamic change lagging the broadband spectral change of EEG by ∼5 s. The levels of global and nonspecific fluctuation and synchronization in scale-free population activity also varied across and depended on arousal states. Together, these results suggest that the neural origin of global resting-state fMRI activity is the broadband power fluctuation in scale-free population activity observable with macrosc...Continue Reading

References

Sep 11, 2016·NeuroImage·Thomas T Liu
Feb 13, 2018·Brain Connectivity·Jacob Billings, Shella D Keilholz
Mar 2, 2018·Annual Review of Biomedical Engineering·Bin HeZhongming Liu
Apr 18, 2020·Human Brain Mapping·Thomas H AldersonDamien Coyle
Dec 6, 2019·Brain Structure & Function·Yuncong MaNanyin Zhang
Jul 29, 2020·ELife·Janna D LendnerRobert T Knight
Oct 18, 2019·Frontiers in Behavioral Neuroscience·Vicente MedelGonzalo Boncompte
Jul 4, 2018·Scientific Reports·Michaël E BelloyMarleen Verhoye

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