Broadband optical mammography: chromophore concentration and hemoglobin saturation contrast in breast cancer

PloS One
Pamela G AndersonSergio Fantini

Abstract

This study reports the optical characterization and quantitative oximetry of human breast cancer using spectrally-resolved images collected with a broadband, continuous-wave optical mammography instrument. On twenty-six cancer patients, we collected two-dimensional optical mammograms and created maps of the concentrations of hemoglobin, water, and lipids, as well as the oxygen saturation of hemoglobin. For each cancerous breast, we analyzed the difference between the tumor region (as identified by x-ray and optical mammography) and the remainder of breast tissue. With respect to the surrounding tissue, we found that cancer regions have significantly higher concentrations of total hemoglobin (+2.4 ± 0.4 μM) and water (+7 ± 1% v/v), and significantly lower lipid concentration (8 ± 2% v/v) and oxygen saturation of hemoglobin (5 ± 1%). We also found a significant correlation between the tumor optical contrast and the grade of breast cancer as quantified by the Nottingham histologic score; this demonstrates how optical signatures may be representative of metabolic and morphological features, as well as the aggressive potential of the tumor.

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Citations

Mar 5, 2016·The Review of Scientific Instruments·Nishanth KrishnamurthySergio Fantini
Aug 24, 2017·Journal of Biomedical Optics·Constance M RobbinsJana M Kainerstorfer
Aug 2, 2017·Journal of Biomedical Optics·Matthew B Applegate, Darren Roblyer
Feb 6, 2016·Journal of Biomedical Optics·Pamela G AndersonSergio Fantini
Oct 27, 2018·Journal of Cellular Physiology·Gary E CarverGary S Stein
Feb 6, 2018·Journal of Lasers in Medical Sciences·Parinaz MehnatiFarhood Fahima
Aug 31, 2020·Particle & Particle Systems Characterization : Measurement and Description of Particle Properties and Behavior in Powders and Other Disperse Systems·Junxin WangJesse V Jokerst
Sep 21, 2020·Journal of Biophotonics·Ghayathri BalasundaramMalini Olivo
Nov 11, 2020·Lasers in Surgery and Medicine·Maha AlgarawiFarouk Nouizi

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Methods Mentioned

BETA
biopsy
X-ray
imaging techniques
imaging technique

Software Mentioned

R
Matlab

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