Broadly Neutralizing Antibodies against HIV: Back to Blood

Trends in Molecular Medicine
Amir DashtiMohammad M Sajadi

Abstract

After years of continuous exposure to HIV envelope antigens, a minority of HIV-infected individuals develop a cognate polyclonal humoral response comprising very potent and extremely cross-reactive neutralizing antibodies [broadly neutralizing antibodies (bNAbs)]. Isolated bNAbs derived from memory B cell pools have been the focus of intense studies over the past decade. However, it is not yet known how to translate the features of bNAbs into practical HIV prevention methods. In this review, we attempt to seek insights from emerging information about the human broadly neutralizing plasma response as well as its frequency, clonal composition, specificity, potency, and commonality among infected subjects. We also consider how this information points to selecting and prioritizing certain epitope targets and strategies for HIV vaccine design.

Citations

Apr 8, 2020·Frontiers in Immunology·José M Martinez-NavioRonald C Desrosiers
Dec 4, 2019·Expert Review of Vaccines·Iván Del Moral-Sánchez, Kwinten Sliepen
Jun 19, 2019·Current HIV Research·Mona Sadat LarijaniSeyed Mehdi Sadat
Jan 11, 2020·Frontiers in Immunology·Bin SuChristiane Moog
Jul 10, 2021·Cell Host & Microbe·Will FischerBette Korber
Jul 28, 2021·Human Vaccines & Immunotherapeutics·Alison Schaefer, Samuel K Lai
Nov 6, 2021·Frontiers in Immunology·Sarah A Griffith, Laura E McCoy
Nov 19, 2020·Immunity·Samuel W KazerAlex K Shalek

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