Broadly reactive immunofluorescence test for measurement of immunoglobulin M and G antibodies to Ureaplasma urealyticum in infant and adult sera.

Journal of Clinical Microbiology
D GalloG E Kenny

Abstract

The indirect immunofluorescence test was used to measure immunoglobulin M (IgM) and IgG antibodies to acetone-fixed Ureaplasma urealyticum organisms in sera from 128 adults with genital infections and from 713 symptomatic newborns and babies 1 day to 18 months old. Thirty-four percent of the adults had demonstrable IgG antibody to ureaplasma. IgM antibody was detected in 2 of the adult sera and in 17 of the infant sera. These babies were divided into two distinct groups. Ten of the infants presented at birth with various physical findings, whereas the onset of symptoms for the other 7 occurred 3 to 13 weeks after birth, and the major clinical finding in 6 of the 7 was respiratory distress. The results of this study suggested that U. urealyticum infection may be associated with fetal damage and infant pneumonia, and if this is substantiated, the indirect immunofluorescence test employing acetone-fixed antigen to measure IgM antibody to U. urealyticum may be an important diagnostic tool.

References

Oct 1, 1977·Journal of Bacteriology·G E Kenny, F D Cartwright
Dec 1, 1972·The Journal of Infectious Diseases·J S LinE H Kass
Jun 1, 1970·The Journal of Infectious Diseases·H M FoyJ T Grayston
Jul 1, 1966·Journal of Bacteriology·R H PurcellR M Chanock
May 1, 1980·The New England Journal of Medicine·D Taylor-Robinson, W M McCormack
Apr 1, 1971·Infection and Immunity·G E Kenny

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Citations

May 1, 1984·Acta paediatrica Scandinavica·D Taylor-RobinsonM M Liberman
Oct 15, 2005·Clinical Microbiology Reviews·Ken B WaitesRobert L Schelonka
Jan 1, 1993·Clinical Microbiology Reviews·G H CassellR Harasawa
Oct 1, 1987·Journal of Clinical Microbiology·G Y Lee, G E Kenny
Aug 1, 1984·Current Problems in Pediatrics·P H AzimiA M Petru
Jun 1, 1986·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J KimpenA Van Waes

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