Broadly tunable dual-wavelength light source for coherent anti-Stokes Raman scattering microscopy

Optics Letters
Feruz GanikhanovDaniel Kopf

Abstract

The signal and idler beams from a picosecond, synchronously pumped optical parametric oscillator (OPO) provide the two colors necessary for coherent anti-Stokes Raman scattering (CARS) microscopy. The OPO provides a continuously tunable frequency difference between the two beams over a broad range of Raman shifts (100-3700 cm(-1)) by varying the temperature of a single nonlinear crystal. The near-infrared output (900-1300 nm) allows for deep penetration into thick samples and reduced nonlinear photodamage. Applications of this light source to in vivo cell and ex vivo tissue imaging are demonstrated.

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Citations

Dec 2, 2009·The Review of Scientific Instruments·Jiun-Yann YuShi-Wei Chu
May 13, 2010·Journal of Biomedical Optics·Fredrik SvedbergAnnika Enejder
Mar 3, 2011·Journal of Biomedical Optics·Sophie BrustleinHervé Rigneault
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Oct 1, 2019·Biomedical Optics Express·Maximilian BrinkmannCarsten Fallnich
Jun 1, 2016·Optics Letters·Lorena Velázquez-IbarraMiguel V Andrés

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