Brodalumab to the Rescue: Efficacy and Safety of Brodalumab in Patients with Psoriasis and Prior Exposure or Inadequate Response to Biologics.

Dermatology and Therapy
Alan MenterAbby A Jacobson

Abstract

While biologic therapies for psoriasis are effective for many patients, some patients may lose response, have inadequate control of disease, or develop intolerance to certain biologic agents. It may therefore be beneficial for patients whose psoriasis fails to respond to one biologic to switch to a different biologic therapy, in particular one with a different mechanism of action. However, it remains unclear how prior biologic exposure or lack of response affects the efficacy and safety of subsequent biologics in patients with moderate-to-severe psoriasis. Brodalumab, a fully human anti-interleukin-17 receptor A monoclonal antibody, has previously been shown to be efficacious in treating moderate-to-severe psoriasis in three large phase 3 trials (AMAGINE-1, AMAGINE-2, and AMAGINE-3). In this review, we summarize the efficacy and safety of brodalumab in patients with moderate-to-severe psoriasis and a history of biologic exposure. Further, we describe improvements in skin clearance and quality of life measures as well as safety in patients who had inadequate response to ustekinumab and who were rescued with brodalumab therapy. Lastly, we discuss improvements in skin clearance following rescue with brodalumab in patients whose di...Continue Reading

References

Mar 30, 2012·The New England Journal of Medicine·Kim A PappScott Baumgartner
Mar 22, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chris B RussellDavid A Martin
Oct 1, 2015·The New England Journal of Medicine·Mark LebwohlAjay Nirula
May 11, 2017·The Journal of Dermatology·Hiromi HondaHidemi Nakagawa
Feb 18, 2019·Journal of the American Academy of Dermatology·Alan MenterCraig A Elmets
May 13, 2019·Journal of the American Academy of Dermatology·Grace KimmelMark Lebwohl

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